Determinants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with Mesotrypsin

An important functional property of protein protease inhibitors is their stability to proteolysis. Mesotrypsin is a human trypsin that has been implicated in the proteolytic inactivation of several protein protease inhibitors. We have found that bovine pancreatic trypsin inhibitor (BPTI), a Kunitz p...

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Veröffentlicht in:	The Journal of biological chemistry 2010-11, Vol.285 (47), p.36884-36896
Hauptverfasser:	Salameh, Moh'd A., Soares, Alexei S., Navaneetham, Duraiswamy, Sinha, Dipali, Walsh, Peter N., Radisky, Evette S.
Format:	Artikel
Sprache:	eng
Schlagworte:	AFFINITY Amino Acid Sequence Amyloid beta-Protein Precursor - chemistry Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Aprotinin - chemistry Aprotinin - genetics Aprotinin - metabolism BASIC BIOLOGICAL SCIENCES CATTLE CLEAVAGE CRYSTAL STRUCTURE Crystallization Crystallography, X-Ray Enzyme Catalysis Enzyme Inhibitors Enzyme Kinetics Enzymology FLEXIBILITY FUNCTIONALS GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE Humans Hydrolysis INACTIVATION Models, Molecular Molecular Sequence Data Peptidases PRECURSOR Protease Protease Inhibitor Protein Binding Protein Conformation Protein-Protein Interactions PROTEINS PROTEOLYSIS Proteolytic Enzymes Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism RESIDUES Sequence Homology, Amino Acid Serine Protease STABILITY THERMODYNAMICS TRYPSIN Trypsin - metabolism VULNERABILITY
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