Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell Invasion

Dysregulation of microRNAs is observed in many cancers, including breast cancer. In particular, miR-10b appears to play an important role in tumor cell invasion and breast cancer progression. In this study, we investigated hyaluronan (HA)-induced CD44 (a primary HA receptor) interaction with c-Src k...

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Veröffentlicht in:	The Journal of biological chemistry 2010-11, Vol.285 (47), p.36721-36735
Hauptverfasser:	Bourguignon, Lilly Y.W., Wong, Gabriel, Earle, Christine, Krueger, Katherine, Spevak, Christina C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - metabolism Apoptosis Blotting, Western Breast Cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Adhesion Cell Movement Cell Proliferation Cell Surface Receptor Chromatin Immunoprecipitation CSK Tyrosine-Protein Kinase Cytoskeleton Cytoskeleton - metabolism Female Fluorescent Antibody Technique Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Hyaluronate Hyaluronic Acid - metabolism Immunoenzyme Techniques MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Neoplasm Invasiveness Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Reverse Transcriptase Polymerase Chain Reaction rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism rho-Associated Kinases - genetics rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism rhoC GTP-Binding Protein RNA, Messenger - genetics RNA, Small Interfering - genetics Signal Transduction src-Family Kinases Transcription Factors - genetics Transcription Factors - metabolism Tumor Cells, Cultured Twist-Related Protein 1 - antagonists & inhibitors Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism
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