Modulation of thermal stability can enhance the potency of siRNA

During RNA-induced silencing complex (RISC) assembly the guide (or antisense) strand has to separate from its complementary passenger (or sense) strand to generate the active RISC complex. Although this process was found to be facilitated through sense strand cleavage, there is evidence for an alter...

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Veröffentlicht in:	Nucleic acids research 2010-11, Vol.38 (20), p.7320-7331
Hauptverfasser:	Addepalli, Haripriya, Meena, Peng, Chang G, Wang, Gang, Fan, Yupeng, Charisse, Klaus, Jayaprakash, K Narayanannair, Rajeev, Kallanthottathil G, Pandey, Rajendra K, Lavine, Gary, Zhang, Ligang, Jahn-Hofmann, Kerstin, Hadwiger, Philipp, Manoharan, Muthiah, Maier, Martin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pair Mismatch HeLa Cells Humans RNA Interference RNA Stability RNA, Small Interfering - chemistry Synthetic Biology and Chemistry Thermodynamics
Online-Zugang:	Volltext
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