Metabolic Control of Vesicular Glutamate Transport and Release

Fasting has been used to control epilepsy since antiquity, but the mechanism of coupling between metabolic state and excitatory neurotransmission remains unknown. Previous work has shown that the vesicular glutamate transporters (VGLUTs) required for exocytotic release of glutamate undergo an unusua...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2010-10, Vol.68 (1), p.99-112
Hauptverfasser:	Juge, Narinobu, Gray, John A., Omote, Hiroshi, Miyaji, Takaaki, Inoue, Tsuyoshi, Hara, Chiaki, Uneyama, Hisayuki, Edwards, Robert H., Nicoll, Roger A., Moriyama, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - pharmacology Acetoacetates - pharmacology Animals Astrocytes - drug effects Astrocytes - physiology Behavior Behavior, Animal Brain research Cells, Cultured Chlorides - metabolism Chromatography, High Pressure Liquid - methods Disease Models, Animal Dopamine - metabolism Dose-Response Relationship, Drug Embryo, Mammalian Epilepsy Excitatory Postsynaptic Potentials - drug effects Exocytosis - drug effects Exocytosis - genetics Gene Expression Regulation Glutamic Acid - metabolism Hippocampus - cytology Humans In Vitro Techniques Ketone Bodies Membrane Potential, Mitochondrial - drug effects Membrane Potential, Mitochondrial - genetics Metabolites Mice Mice, Inbred C57BL Microdialysis - methods Models, Biological Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques - methods Potassium Channel Blockers - pharmacology Rats Rodents Seizures - chemically induced Seizures - physiopathology Studies Synaptic Vesicles - metabolism Vesicular Glutamate Transport Protein 2 - chemistry Vesicular Glutamate Transport Protein 2 - genetics Vesicular Glutamate Transport Protein 2 - metabolism
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