Intestinal Mesenchymal Cells
The non–white blood cell mesenchymal elements of the intestinal lamina propria are the myofibroblasts, fibroblasts, pericytes, stromal stem cells, muscularis mucosae, and the smooth muscle of the villus core associated with the lymphatic lacteal. We review the functional anatomy of these mesenchymal...
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| Veröffentlicht in: | Current gastroenterology reports 2010-10, Vol.12 (5), p.310-318 |
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| creator | Pinchuk, I. V. Mifflin, R. C. Saada, J. I. Powell, D. W. |
| description | The non–white blood cell mesenchymal elements of the intestinal lamina propria are the myofibroblasts, fibroblasts, pericytes, stromal stem cells, muscularis mucosae, and the smooth muscle of the villus core associated with the lymphatic lacteal. We review the functional anatomy of these mesenchymal cells, what is known about their origin in the embryo and their replacement in adults, their putative role in intestinal mucosal morphogenesis, and the intestinal stem cell niche, and we consider new information about myofibroblasts as nonprofessional immune cells. Although our knowledge of the function of mesenchymal cells in intestinal disease is rudimentary, we briefly consider here their roles in cancer and intestinal inflammation. |
| doi_str_mv | 10.1007/s11894-010-0135-y |
| format | Article |
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V.</creatorcontrib><creatorcontrib>Mifflin, R. C.</creatorcontrib><creatorcontrib>Saada, J. I.</creatorcontrib><creatorcontrib>Powell, D. W.</creatorcontrib><title>Intestinal Mesenchymal Cells</title><title>Current gastroenterology reports</title><addtitle>Curr Gastroenterol Rep</addtitle><addtitle>Curr Gastroenterol Rep</addtitle><description>The non–white blood cell mesenchymal elements of the intestinal lamina propria are the myofibroblasts, fibroblasts, pericytes, stromal stem cells, muscularis mucosae, and the smooth muscle of the villus core associated with the lymphatic lacteal. We review the functional anatomy of these mesenchymal cells, what is known about their origin in the embryo and their replacement in adults, their putative role in intestinal mucosal morphogenesis, and the intestinal stem cell niche, and we consider new information about myofibroblasts as nonprofessional immune cells. Although our knowledge of the function of mesenchymal cells in intestinal disease is rudimentary, we briefly consider here their roles in cancer and intestinal inflammation.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Bone marrow</subject><subject>Brain-derived neurotrophic factor</subject><subject>Cell Communication</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Cytokines</subject><subject>Disease</subject><subject>Endoderm - cytology</subject><subject>Epithelial Cells - cytology</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Fibroblasts</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Inflammation - pathology</subject><subject>Intestinal Mucosa - cytology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesenchymal Stromal Cells</subject><subject>Mesoderm - cytology</subject><subject>Mice</subject><subject>Morphogenesis</subject><subject>Mucous Membrane</subject><subject>Muscle, Smooth</subject><subject>Myofibroblasts - cytology</subject><subject>Myofibroblasts - pathology</subject><subject>Pericytes</subject><subject>Smooth muscle</subject><subject>Stem cells</subject><subject>Stromal Cells - immunology</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vascular endothelial growth factor</subject><issn>1522-8037</issn><issn>1534-312X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1UF1LwzAUDaK4Of0Bgojgc_UmadrmRZDhx2Dii4JvoU1ut46unckm9N97R-fXgw8hB-45595zGDvlcMUB0uvAeabjCDjQkyrq9tiQKxlHkou3_S0WIspApgN2FMICQJAqOWQDAYkGgHjIzibNGsO6avL64gkDNnbeLQmPsa7DMTso8zrgye4fsdf7u5fxYzR9fpiMb6eRlVncRcLJQintUCWFSJx12ooCU4cijp21CJbnhYRM5YAEk9JZpdHFJMlKJ7gcsZved7UplugsNmuf12blq2XuO9Pmlfk7aaq5mbUfRuhUaaXI4HJn4Nv3DeUxi3bjKVMgCs_SRFFYYvGeZX0bgsfyewMHsy3U9IUaKtRsCzUdac5_n_at-GqQCKInBBo1M_Q_q_93_QQrIIH7</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Pinchuk, I. V.</creator><creator>Mifflin, R. C.</creator><creator>Saada, J. I.</creator><creator>Powell, D. W.</creator><general>Current Science Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>201010</creationdate><title>Intestinal Mesenchymal Cells</title><author>Pinchuk, I. V. ; Mifflin, R. C. ; Saada, J. I. ; Powell, D. 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V.</au><au>Mifflin, R. C.</au><au>Saada, J. I.</au><au>Powell, D. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal Mesenchymal Cells</atitle><jtitle>Current gastroenterology reports</jtitle><stitle>Curr Gastroenterol Rep</stitle><addtitle>Curr Gastroenterol Rep</addtitle><date>2010-10</date><risdate>2010</risdate><volume>12</volume><issue>5</issue><spage>310</spage><epage>318</epage><pages>310-318</pages><issn>1522-8037</issn><eissn>1534-312X</eissn><abstract>The non–white blood cell mesenchymal elements of the intestinal lamina propria are the myofibroblasts, fibroblasts, pericytes, stromal stem cells, muscularis mucosae, and the smooth muscle of the villus core associated with the lymphatic lacteal. 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| subjects | Animals Biomarkers Bone marrow Brain-derived neurotrophic factor Cell Communication Cell Transformation, Neoplastic - pathology Cytokines Disease Endoderm - cytology Epithelial Cells - cytology Epithelial-Mesenchymal Transition Fibroblasts Gastroenterology Humans Inflammation - pathology Intestinal Mucosa - cytology Medicine Medicine & Public Health Mesenchymal Stromal Cells Mesoderm - cytology Mice Morphogenesis Mucous Membrane Muscle, Smooth Myofibroblasts - cytology Myofibroblasts - pathology Pericytes Smooth muscle Stem cells Stromal Cells - immunology Tumor necrosis factor-TNF Vascular endothelial growth factor |
| title | Intestinal Mesenchymal Cells |
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