Rat psychomotor vigilance task with fast response times using a conditioned lick behavior
▶ The psychomotor vigilance task is a widely used test of simple reaction times and is a sensitive measure of sleep deprivation. ▶ Sucrose can be used as a reinforcer to maintain responding in conditioned learning paradigms without the need for deprivation. ▶ A significant decrease in percent correc...
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| Veröffentlicht in: | Behavioural brain research 2011-01, Vol.216 (1), p.229-237 |
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| creator | Walker, Jennifer L. Walker, Brendan M. Fuentes, Fernanda Monjaraz Rector, David M. |
| description | ▶ The psychomotor vigilance task is a widely used test of simple reaction times and is a sensitive measure of sleep deprivation. ▶ Sucrose can be used as a reinforcer to maintain responding in conditioned learning paradigms without the need for deprivation. ▶ A significant decrease in percent correct hits occurred following 6 and 12
h of sleep deprivation and reaction times increased significantly following 12
h of sleep deprivation. ▶ Increases in EEG delta power and lower EMG power were observed prior to misses during sleep deprivation sessions. ▶ An increase in evoked response peak amplitudes was observed during conditioning, suggesting that plasticity may occur with conditioned learning.
Investigations into the physiological mechanisms of sleep control require an animal psychomotor vigilance task (PVT) with fast response times ( |
| doi_str_mv | 10.1016/j.bbr.2010.07.041 |
| format | Article |
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h of sleep deprivation and reaction times increased significantly following 12
h of sleep deprivation. ▶ Increases in EEG delta power and lower EMG power were observed prior to misses during sleep deprivation sessions. ▶ An increase in evoked response peak amplitudes was observed during conditioning, suggesting that plasticity may occur with conditioned learning.
Investigations into the physiological mechanisms of sleep control require an animal psychomotor vigilance task (PVT) with fast response times (<300
ms). Rats provide a good PVT model since whisker stimulation produces a rapid and robust cortical evoked response, and animals can be trained to lick following stimulation. Our prior experiments used deprivation-based approaches to maximize motivation for operant conditioned responses. However, deprivation can influence physiological and neurobehavioral effects. In order to maintain motivation without water deprivation, we conditioned rats for immobilization and head restraint, then trained them to lick for a 10% sucrose solution in response to whisker stimulation. After approximately 8 training sessions, animals produced greater than 80% correct hits to the stimulus. Over the course of training, reaction times became faster and correct hits increased. Performance in the PVT was examined after 3, 6 and 12
h of sleep deprivation achieved by gentle handling. A significant decrease in percent correct hits occurred following 6 and 12
h of sleep deprivation and reaction times increased significantly following 12
h of sleep deprivation. While behaviorally the animals appeared to be awake, we observed significant increases in EEG delta power prior to misses. The rat PVT with fast response times allows investigation of sleep deprivation effects, time-on-task and pharmacological agents. Fast response times also allow closer parallel studies to ongoing human protocols.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2010.07.041</identifier><identifier>PMID: 20696188</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Analysis of Variance ; Animals ; Arousal - physiology ; Attention - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Conditioned learning ; Conditioning (Psychology) - physiology ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Electrodes, Implanted ; Electroencephalography ; Electrophysiology ; Female ; Fundamental and applied biological sciences. Psychology ; Lick ; Medical sciences ; Motivation - physiology ; Nervous system (semeiology, syndromes) ; Neurology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychomotor Performance - physiology ; PVT ; Rats ; Rats, Sprague-Dawley ; Reaction time ; Reaction Time - physiology ; Restraint ; Restraint, Physical ; Sleep - physiology ; Sleep deprivation ; Sleep Deprivation - physiopathology ; Somatosensory cortex</subject><ispartof>Behavioural brain research, 2011-01, Vol.216 (1), p.229-237</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><rights>2010 Elsevier B.V. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-23a6f07933c362b67ef711299dbcf13d781dd0e7f8bed5665d41ec2f8ed9333e3</citedby><cites>FETCH-LOGICAL-c512t-23a6f07933c362b67ef711299dbcf13d781dd0e7f8bed5665d41ec2f8ed9333e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbr.2010.07.041$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23436818$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20696188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walker, Jennifer L.</creatorcontrib><creatorcontrib>Walker, Brendan M.</creatorcontrib><creatorcontrib>Fuentes, Fernanda Monjaraz</creatorcontrib><creatorcontrib>Rector, David M.</creatorcontrib><title>Rat psychomotor vigilance task with fast response times using a conditioned lick behavior</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>▶ The psychomotor vigilance task is a widely used test of simple reaction times and is a sensitive measure of sleep deprivation. ▶ Sucrose can be used as a reinforcer to maintain responding in conditioned learning paradigms without the need for deprivation. ▶ A significant decrease in percent correct hits occurred following 6 and 12
h of sleep deprivation and reaction times increased significantly following 12
h of sleep deprivation. ▶ Increases in EEG delta power and lower EMG power were observed prior to misses during sleep deprivation sessions. ▶ An increase in evoked response peak amplitudes was observed during conditioning, suggesting that plasticity may occur with conditioned learning.
Investigations into the physiological mechanisms of sleep control require an animal psychomotor vigilance task (PVT) with fast response times (<300
ms). Rats provide a good PVT model since whisker stimulation produces a rapid and robust cortical evoked response, and animals can be trained to lick following stimulation. Our prior experiments used deprivation-based approaches to maximize motivation for operant conditioned responses. However, deprivation can influence physiological and neurobehavioral effects. In order to maintain motivation without water deprivation, we conditioned rats for immobilization and head restraint, then trained them to lick for a 10% sucrose solution in response to whisker stimulation. After approximately 8 training sessions, animals produced greater than 80% correct hits to the stimulus. Over the course of training, reaction times became faster and correct hits increased. Performance in the PVT was examined after 3, 6 and 12
h of sleep deprivation achieved by gentle handling. A significant decrease in percent correct hits occurred following 6 and 12
h of sleep deprivation and reaction times increased significantly following 12
h of sleep deprivation. While behaviorally the animals appeared to be awake, we observed significant increases in EEG delta power prior to misses. The rat PVT with fast response times allows investigation of sleep deprivation effects, time-on-task and pharmacological agents. Fast response times also allow closer parallel studies to ongoing human protocols.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Arousal - physiology</subject><subject>Attention - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Conditioned learning</subject><subject>Conditioning (Psychology) - physiology</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Electrodes, Implanted</subject><subject>Electroencephalography</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lick</subject><subject>Medical sciences</subject><subject>Motivation - physiology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychomotor Performance - physiology</subject><subject>PVT</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reaction time</subject><subject>Reaction Time - physiology</subject><subject>Restraint</subject><subject>Restraint, Physical</subject><subject>Sleep - physiology</subject><subject>Sleep deprivation</subject><subject>Sleep Deprivation - physiopathology</subject><subject>Somatosensory cortex</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEURoMoTjv6A9xINuKqevKoPApBkMEXDAjDuHAVUsmt7vRUVdok3TL_3jTdjs5GVyHJ-S733oPQS0qWlFB5sVn2fVoyUu9ELUlLH6EF1Yo1SrTdY7SojGxazvQZepbzhhDSEkGfojNGZCep1gv0_doWvM13bh2nWGLC-7AKo50d4GLzLf4ZyhoPNhecIG_jnOt7mCDjXQ7zClvs4uxDCXEGj8fgbnEPa7sPMT1HTwY7ZnhxOs_Rt48fbi4_N1dfP325fH_VOEFZaRi3ciCq49xxyXqpYFCUsq7zvRso90pT7wmoQffghZTCtxQcGzT4muHAz9G7Y93trp_AO5hLsqPZpjDZdGeiDebhzxzWZhX3hnVKaMVrgTenAin-2EEuZgrZwVi3AHGXjRa8VYII9l9SSU6V7ASpJD2SLsWcEwz3_VBiDu7MxlR35uDOEGWqu5p59fcg94nfsirw-gTY7Ow4pKop5D8cb7nU9MC9PXJQ174PkEx2AapSHxK4YnwM_2jjF3C8uOA</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Walker, Jennifer L.</creator><creator>Walker, Brendan M.</creator><creator>Fuentes, Fernanda Monjaraz</creator><creator>Rector, David M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Rat psychomotor vigilance task with fast response times using a conditioned lick behavior</title><author>Walker, Jennifer L. ; Walker, Brendan M. ; Fuentes, Fernanda Monjaraz ; Rector, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-23a6f07933c362b67ef711299dbcf13d781dd0e7f8bed5665d41ec2f8ed9333e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Arousal - physiology</topic><topic>Attention - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Conditioned learning</topic><topic>Conditioning (Psychology) - physiology</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Electrodes, Implanted</topic><topic>Electroencephalography</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lick</topic><topic>Medical sciences</topic><topic>Motivation - physiology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychomotor Performance - physiology</topic><topic>PVT</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reaction time</topic><topic>Reaction Time - physiology</topic><topic>Restraint</topic><topic>Restraint, Physical</topic><topic>Sleep - physiology</topic><topic>Sleep deprivation</topic><topic>Sleep Deprivation - physiopathology</topic><topic>Somatosensory cortex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walker, Jennifer L.</creatorcontrib><creatorcontrib>Walker, Brendan M.</creatorcontrib><creatorcontrib>Fuentes, Fernanda Monjaraz</creatorcontrib><creatorcontrib>Rector, David M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walker, Jennifer L.</au><au>Walker, Brendan M.</au><au>Fuentes, Fernanda Monjaraz</au><au>Rector, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rat psychomotor vigilance task with fast response times using a conditioned lick behavior</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>216</volume><issue>1</issue><spage>229</spage><epage>237</epage><pages>229-237</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>▶ The psychomotor vigilance task is a widely used test of simple reaction times and is a sensitive measure of sleep deprivation. ▶ Sucrose can be used as a reinforcer to maintain responding in conditioned learning paradigms without the need for deprivation. ▶ A significant decrease in percent correct hits occurred following 6 and 12
h of sleep deprivation and reaction times increased significantly following 12
h of sleep deprivation. ▶ Increases in EEG delta power and lower EMG power were observed prior to misses during sleep deprivation sessions. ▶ An increase in evoked response peak amplitudes was observed during conditioning, suggesting that plasticity may occur with conditioned learning.
Investigations into the physiological mechanisms of sleep control require an animal psychomotor vigilance task (PVT) with fast response times (<300
ms). Rats provide a good PVT model since whisker stimulation produces a rapid and robust cortical evoked response, and animals can be trained to lick following stimulation. Our prior experiments used deprivation-based approaches to maximize motivation for operant conditioned responses. However, deprivation can influence physiological and neurobehavioral effects. In order to maintain motivation without water deprivation, we conditioned rats for immobilization and head restraint, then trained them to lick for a 10% sucrose solution in response to whisker stimulation. After approximately 8 training sessions, animals produced greater than 80% correct hits to the stimulus. Over the course of training, reaction times became faster and correct hits increased. Performance in the PVT was examined after 3, 6 and 12
h of sleep deprivation achieved by gentle handling. A significant decrease in percent correct hits occurred following 6 and 12
h of sleep deprivation and reaction times increased significantly following 12
h of sleep deprivation. While behaviorally the animals appeared to be awake, we observed significant increases in EEG delta power prior to misses. The rat PVT with fast response times allows investigation of sleep deprivation effects, time-on-task and pharmacological agents. Fast response times also allow closer parallel studies to ongoing human protocols.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>20696188</pmid><doi>10.1016/j.bbr.2010.07.041</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Analysis of Variance Animals Arousal - physiology Attention - physiology Behavioral psychophysiology Biological and medical sciences Conditioned learning Conditioning (Psychology) - physiology Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Electrodes, Implanted Electroencephalography Electrophysiology Female Fundamental and applied biological sciences. Psychology Lick Medical sciences Motivation - physiology Nervous system (semeiology, syndromes) Neurology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - physiology PVT Rats Rats, Sprague-Dawley Reaction time Reaction Time - physiology Restraint Restraint, Physical Sleep - physiology Sleep deprivation Sleep Deprivation - physiopathology Somatosensory cortex |
| title | Rat psychomotor vigilance task with fast response times using a conditioned lick behavior |
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