A genetic survey of fluoxetine action on synaptic transmission in Caenorhabditis elegans

Fluoxetine is one of the most commonly prescribed medications for many behavioral and neurological disorders. Fluoxetine acts primarily as an inhibitor of the serotonin reuptake transporter (SERT) to block the removal of serotonin from the synaptic cleft, thereby enhancing serotonin signals. While t...

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Veröffentlicht in:	Genetics (Austin) 2010-11, Vol.186 (3), p.929-941
Hauptverfasser:	Kullyev, Andrey, Dempsey, Catherine M, Miller, Sarah, Kuan, Chih-Jen, Hapiak, Vera M, Komuniecki, Richard W, Griffin, Christine T, Sze, Ji Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Antidepressants Behavior, Animal - drug effects Biological Assay Caenorhabditis elegans - drug effects Caenorhabditis elegans - genetics Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism E coli Fluoxetine - metabolism Fluoxetine - pharmacology gamma-Aminobutyric Acid - metabolism Genes Genetics Glutamic Acid - metabolism Investigations Muscle Relaxation - drug effects Mutation - genetics Nematodes Neurons - drug effects Neurons - metabolism Receptors, Serotonin - genetics Receptors, Serotonin - metabolism Selective Serotonin Reuptake Inhibitors - pharmacology Serotonin - metabolism Serotonin - pharmacology Signal Transduction - drug effects Synaptic Transmission - drug effects
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