Functional Rescue of a Misfolded Eukaryotic ATP-binding Cassette Transporter by Domain Replacement

ATP-binding cassette (ABC) transporters are integral membrane proteins that couple ATP binding/hydrolysis with the transport of hydrophilic substrates across lipid barriers. Deletion of Phe-670 in the first nucleotide-binding domain (NBD1) of the yeast ABC transporter, Yor1p, perturbs interdomain as...

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Veröffentlicht in:	The Journal of biological chemistry 2010-11, Vol.285 (46), p.36225-36234
Hauptverfasser:	Louie, Raymond J., Pagant, Silvere, Youn, Ji-Young, Halliday, John J., Huyer, Gregory, Michaelis, Susan, Miller, Elizabeth A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC Transporter ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Binding Sites - genetics Cell Membrane - metabolism Cell Surface Protein Drug Resistance Endoplasmic Reticulum - metabolism Eukaryotic Cells - metabolism Genetic Complementation Test - methods Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Immunoblotting Intracellular Trafficking Microscopy, Confocal Mutation Protein Folding Protein Structure and Folding Protein Transport Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Deletion Transcomplementation Yeast
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