polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus

Aims/hypothesis Homozygosity for a five leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We prospectively investigated in patients with type 1 diabetes whether: (1) 5...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Diabetologia 2010-12, Vol.53 (12), p.2562-2568
Hauptverfasser:	Alkhalaf, A, Bakker, S. J. L, Bilo, H. J. G, Gans, R. O. B, Navis, G. J, Postmus, D, Forsblom, C, Groop, P. H, Vionnet, N, Hadjadj, S, Marre, M, Parving, H. H, Rossing, P, Tarnow, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Associated diseases and complications Biological and medical sciences Carnosinase gene Case-Control Studies CNDP1 Cross-sectional studies Diabetes Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - mortality Diabetes. Impaired glucose tolerance Diabetic Nephropathies - diagnosis Diabetic Nephropathies - genetics Diabetic Nephropathies - mortality Diabetic nephropathy Dipeptidases - genetics Disease Progression End-stage renal disease Endocrine pancreas. Apud cells (diseases) Endocrinology Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance European Continental Ancestry Group - genetics Female Five leucine repeat Follow-Up Studies Genetic Predisposition to Disease Health risk assessment Human Physiology Humans insulin-dependent diabetes mellitus Internal Medicine Kidney diseases Kidney Failure, Chronic - diagnosis Kidney Failure, Chronic - etiology Kidney Failure, Chronic - genetics Kidney Failure, Chronic - mortality Kidneys Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Mortality Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Polymorphism Polymorphism, Single Nucleotide - physiology Prognosis Renal failure Survival Analysis Urinary system involvement in other diseases. Miscellaneous
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!