polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus
Aims/hypothesis Homozygosity for a five leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We prospectively investigated in patients with type 1 diabetes whether: (1) 5...
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| creator | Alkhalaf, A Bakker, S. J. L Bilo, H. J. G Gans, R. O. B Navis, G. J Postmus, D Forsblom, C Groop, P. H Vionnet, N Hadjadj, S Marre, M Parving, H. H Rossing, P Tarnow, L |
| description | Aims/hypothesis Homozygosity for a five leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We prospectively investigated in patients with type 1 diabetes whether: (1) 5L-5L is associated with mortality; (2) there is an interaction of 5L-5L with DN or sex for prediction of mortality; and (3) 5L-5L is associated with progression to end-stage renal disease (ESRD). Methods In this prospective study in white European patients with type 1 diabetes, individuals with DN were defined by persistent albuminuria ≥300 mg/24 h. Controls without nephropathy were defined by persistent (>15 years) normoalbuminuria |
| doi_str_mv | 10.1007/s00125-010-1863-0 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2974933</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>954596893</sourcerecordid><originalsourceid>FETCH-LOGICAL-c620t-ec99076819196e679f7cf9b947b0b93f7473a7e2eca52bfae5c1e16a2f8bd36c3</originalsourceid><addsrcrecordid>eNqFkt-K1TAQh4so7nH1AbzRIIh6UU2aNmluBDn-hUUFXfAuTNNpT5Y26SatcB7JtzTlHHfVC70Kze-brzPtZNl9Rp8zSuWLSCkrqpwymrNa8JzeyDas5EVOy6K-mW3WeE2-nWR3YryglPKqFLezk4JKxiSrN9mPyQ_70YdpZ-NIrCPzDkmPDgk641vremIgOB-tg4jk6fbj68_sGYFIgEwBW2tmH4jvSHLMMNh5T8C1KfJ9wBitd6QLfiQOp13wE8y7PZl9krd5nKFHEtDBQFobcfWvDewnJCzdQIMzRjLikLRLvJvd6mCIeO94nmbnb9983b7Pzz69-7B9dZYbUdA5R6MUlaJmiimBQqpOmk41qpQNbRTvZCk5SCzQQFU0HWBlGDIBRVc3LReGn2YvD95paUZsDbo5wKCnYEcIe-3B6j8TZ3e69991oWSpOE-CJ0dB8JcLxlmPNpo0BTj0S9SqKislavV_UgrOZFlWIpGP_iIv_BLSl4u6prJKP1rWCWIHyAQfY8DuqmlG9bow-rAwmq7PaWE0TTUPfp_2quLXhiTg8RGAaGDoAjhj4zXHS6a4WLniwMUUuR7DdYf_evvDQ1EHXkMfkvj8S0EZp0xRlbz8Jx9y5No</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>807500178</pqid></control><display><type>article</type><title>polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Alkhalaf, A ; Bakker, S. J. L ; Bilo, H. J. G ; Gans, R. O. B ; Navis, G. J ; Postmus, D ; Forsblom, C ; Groop, P. H ; Vionnet, N ; Hadjadj, S ; Marre, M ; Parving, H. H ; Rossing, P ; Tarnow, L</creator><creatorcontrib>Alkhalaf, A ; Bakker, S. J. L ; Bilo, H. J. G ; Gans, R. O. B ; Navis, G. J ; Postmus, D ; Forsblom, C ; Groop, P. H ; Vionnet, N ; Hadjadj, S ; Marre, M ; Parving, H. H ; Rossing, P ; Tarnow, L</creatorcontrib><description>Aims/hypothesis Homozygosity for a five leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We prospectively investigated in patients with type 1 diabetes whether: (1) 5L-5L is associated with mortality; (2) there is an interaction of 5L-5L with DN or sex for prediction of mortality; and (3) 5L-5L is associated with progression to end-stage renal disease (ESRD). Methods In this prospective study in white European patients with type 1 diabetes, individuals with DN were defined by persistent albuminuria ≥300 mg/24 h. Controls without nephropathy were defined by persistent (>15 years) normoalbuminuria <30 mg/24 h. Leucine repeats were assessed with a fluorescent DNA analysis system. Onset of ESRD was defined by need to start chronic dialysis or kidney transplantation. Results The study involved 916 patients with DN and 1,170 controls. During follow-up for 8.8 years, 107 patients (14%) with 5L-5L died compared with 182 patients (13.8%) with other genotypes (p = 0.99). There was no significant interaction of 5L-5L with DN for prediction of mortality (p = 0.57), but a trend towards interaction with sex (p = 0.08). In patients with DN, HR for ESRD in 5L-5L vs other genotypes was not constant over time, with increased risk for 5L-5L beyond 8 years of follow-up (p = 0.03). Conclusions/interpretation CNDP1 polymorphism was not associated with mortality, and nor was there an interaction of this polymorphism with DN for prediction of mortality in patients with type 1 diabetes. CNDP1 polymorphism predicts progression to ESRD in patients with DN, but only late after baseline measurements.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-010-1863-0</identifier><identifier>PMID: 20711718</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Adult ; Associated diseases and complications ; Biological and medical sciences ; Carnosinase gene ; Case-Control Studies ; CNDP1 ; Cross-sectional studies ; Diabetes ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - diagnosis ; Diabetes Mellitus, Type 1 - genetics ; Diabetes Mellitus, Type 1 - mortality ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies - diagnosis ; Diabetic Nephropathies - genetics ; Diabetic Nephropathies - mortality ; Diabetic nephropathy ; Dipeptidases - genetics ; Disease Progression ; End-stage renal disease ; Endocrine pancreas. Apud cells (diseases) ; Endocrinology ; Endocrinopathies ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; European Continental Ancestry Group - genetics ; Female ; Five leucine repeat ; Follow-Up Studies ; Genetic Predisposition to Disease ; Health risk assessment ; Human Physiology ; Humans ; insulin-dependent diabetes mellitus ; Internal Medicine ; Kidney diseases ; Kidney Failure, Chronic - diagnosis ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - genetics ; Kidney Failure, Chronic - mortality ; Kidneys ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Mortality ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Polymorphism ; Polymorphism, Single Nucleotide - physiology ; Prognosis ; Renal failure ; Survival Analysis ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>Diabetologia, 2010-12, Vol.53 (12), p.2562-2568</ispartof><rights>The Author(s) 2010</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-ec99076819196e679f7cf9b947b0b93f7473a7e2eca52bfae5c1e16a2f8bd36c3</citedby><cites>FETCH-LOGICAL-c620t-ec99076819196e679f7cf9b947b0b93f7473a7e2eca52bfae5c1e16a2f8bd36c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00125-010-1863-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00125-010-1863-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23419368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20711718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alkhalaf, A</creatorcontrib><creatorcontrib>Bakker, S. J. L</creatorcontrib><creatorcontrib>Bilo, H. J. G</creatorcontrib><creatorcontrib>Gans, R. O. B</creatorcontrib><creatorcontrib>Navis, G. J</creatorcontrib><creatorcontrib>Postmus, D</creatorcontrib><creatorcontrib>Forsblom, C</creatorcontrib><creatorcontrib>Groop, P. H</creatorcontrib><creatorcontrib>Vionnet, N</creatorcontrib><creatorcontrib>Hadjadj, S</creatorcontrib><creatorcontrib>Marre, M</creatorcontrib><creatorcontrib>Parving, H. H</creatorcontrib><creatorcontrib>Rossing, P</creatorcontrib><creatorcontrib>Tarnow, L</creatorcontrib><title>polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><addtitle>Diabetologia</addtitle><description>Aims/hypothesis Homozygosity for a five leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We prospectively investigated in patients with type 1 diabetes whether: (1) 5L-5L is associated with mortality; (2) there is an interaction of 5L-5L with DN or sex for prediction of mortality; and (3) 5L-5L is associated with progression to end-stage renal disease (ESRD). Methods In this prospective study in white European patients with type 1 diabetes, individuals with DN were defined by persistent albuminuria ≥300 mg/24 h. Controls without nephropathy were defined by persistent (>15 years) normoalbuminuria <30 mg/24 h. Leucine repeats were assessed with a fluorescent DNA analysis system. Onset of ESRD was defined by need to start chronic dialysis or kidney transplantation. Results The study involved 916 patients with DN and 1,170 controls. During follow-up for 8.8 years, 107 patients (14%) with 5L-5L died compared with 182 patients (13.8%) with other genotypes (p = 0.99). There was no significant interaction of 5L-5L with DN for prediction of mortality (p = 0.57), but a trend towards interaction with sex (p = 0.08). In patients with DN, HR for ESRD in 5L-5L vs other genotypes was not constant over time, with increased risk for 5L-5L beyond 8 years of follow-up (p = 0.03). Conclusions/interpretation CNDP1 polymorphism was not associated with mortality, and nor was there an interaction of this polymorphism with DN for prediction of mortality in patients with type 1 diabetes. CNDP1 polymorphism predicts progression to ESRD in patients with DN, but only late after baseline measurements.</description><subject>Adult</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Carnosinase gene</subject><subject>Case-Control Studies</subject><subject>CNDP1</subject><subject>Cross-sectional studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - diagnosis</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Diabetes Mellitus, Type 1 - mortality</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies - diagnosis</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Diabetic Nephropathies - mortality</subject><subject>Diabetic nephropathy</subject><subject>Dipeptidases - genetics</subject><subject>Disease Progression</subject><subject>End-stage renal disease</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinology</subject><subject>Endocrinopathies</subject><subject>Epidemiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Five leucine repeat</subject><subject>Follow-Up Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Health risk assessment</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>insulin-dependent diabetes mellitus</subject><subject>Internal Medicine</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - diagnosis</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - genetics</subject><subject>Kidney Failure, Chronic - mortality</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - physiology</subject><subject>Prognosis</subject><subject>Renal failure</subject><subject>Survival Analysis</subject><subject>Urinary system involvement in other diseases. 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H</creator><creator>Rossing, P</creator><creator>Tarnow, L</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20101201</creationdate><title>polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus</title><author>Alkhalaf, A ; Bakker, S. J. L ; Bilo, H. J. G ; Gans, R. O. B ; Navis, G. J ; Postmus, D ; Forsblom, C ; Groop, P. H ; Vionnet, N ; Hadjadj, S ; Marre, M ; Parving, H. H ; Rossing, P ; Tarnow, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c620t-ec99076819196e679f7cf9b947b0b93f7473a7e2eca52bfae5c1e16a2f8bd36c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Carnosinase gene</topic><topic>Case-Control Studies</topic><topic>CNDP1</topic><topic>Cross-sectional studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - diagnosis</topic><topic>Diabetes Mellitus, Type 1 - genetics</topic><topic>Diabetes Mellitus, Type 1 - mortality</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies - diagnosis</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Diabetic Nephropathies - mortality</topic><topic>Diabetic nephropathy</topic><topic>Dipeptidases - genetics</topic><topic>Disease Progression</topic><topic>End-stage renal disease</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinology</topic><topic>Endocrinopathies</topic><topic>Epidemiology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Five leucine repeat</topic><topic>Follow-Up Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Health risk assessment</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>insulin-dependent diabetes mellitus</topic><topic>Internal Medicine</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic - diagnosis</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - genetics</topic><topic>Kidney Failure, Chronic - mortality</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - physiology</topic><topic>Prognosis</topic><topic>Renal failure</topic><topic>Survival Analysis</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alkhalaf, A</creatorcontrib><creatorcontrib>Bakker, S. J. L</creatorcontrib><creatorcontrib>Bilo, H. J. G</creatorcontrib><creatorcontrib>Gans, R. O. B</creatorcontrib><creatorcontrib>Navis, G. J</creatorcontrib><creatorcontrib>Postmus, D</creatorcontrib><creatorcontrib>Forsblom, C</creatorcontrib><creatorcontrib>Groop, P. H</creatorcontrib><creatorcontrib>Vionnet, N</creatorcontrib><creatorcontrib>Hadjadj, S</creatorcontrib><creatorcontrib>Marre, M</creatorcontrib><creatorcontrib>Parving, H. H</creatorcontrib><creatorcontrib>Rossing, P</creatorcontrib><creatorcontrib>Tarnow, L</creatorcontrib><collection>AGRIS</collection><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alkhalaf, A</au><au>Bakker, S. J. L</au><au>Bilo, H. J. G</au><au>Gans, R. O. B</au><au>Navis, G. J</au><au>Postmus, D</au><au>Forsblom, C</au><au>Groop, P. H</au><au>Vionnet, N</au><au>Hadjadj, S</au><au>Marre, M</au><au>Parving, H. H</au><au>Rossing, P</au><au>Tarnow, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus</atitle><jtitle>Diabetologia</jtitle><stitle>Diabetologia</stitle><addtitle>Diabetologia</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>53</volume><issue>12</issue><spage>2562</spage><epage>2568</epage><pages>2562-2568</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Aims/hypothesis Homozygosity for a five leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We prospectively investigated in patients with type 1 diabetes whether: (1) 5L-5L is associated with mortality; (2) there is an interaction of 5L-5L with DN or sex for prediction of mortality; and (3) 5L-5L is associated with progression to end-stage renal disease (ESRD). Methods In this prospective study in white European patients with type 1 diabetes, individuals with DN were defined by persistent albuminuria ≥300 mg/24 h. Controls without nephropathy were defined by persistent (>15 years) normoalbuminuria <30 mg/24 h. Leucine repeats were assessed with a fluorescent DNA analysis system. Onset of ESRD was defined by need to start chronic dialysis or kidney transplantation. Results The study involved 916 patients with DN and 1,170 controls. During follow-up for 8.8 years, 107 patients (14%) with 5L-5L died compared with 182 patients (13.8%) with other genotypes (p = 0.99). There was no significant interaction of 5L-5L with DN for prediction of mortality (p = 0.57), but a trend towards interaction with sex (p = 0.08). In patients with DN, HR for ESRD in 5L-5L vs other genotypes was not constant over time, with increased risk for 5L-5L beyond 8 years of follow-up (p = 0.03). Conclusions/interpretation CNDP1 polymorphism was not associated with mortality, and nor was there an interaction of this polymorphism with DN for prediction of mortality in patients with type 1 diabetes. CNDP1 polymorphism predicts progression to ESRD in patients with DN, but only late after baseline measurements.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>20711718</pmid><doi>10.1007/s00125-010-1863-0</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Associated diseases and complications Biological and medical sciences Carnosinase gene Case-Control Studies CNDP1 Cross-sectional studies Diabetes Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - mortality Diabetes. Impaired glucose tolerance Diabetic Nephropathies - diagnosis Diabetic Nephropathies - genetics Diabetic Nephropathies - mortality Diabetic nephropathy Dipeptidases - genetics Disease Progression End-stage renal disease Endocrine pancreas. Apud cells (diseases) Endocrinology Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance European Continental Ancestry Group - genetics Female Five leucine repeat Follow-Up Studies Genetic Predisposition to Disease Health risk assessment Human Physiology Humans insulin-dependent diabetes mellitus Internal Medicine Kidney diseases Kidney Failure, Chronic - diagnosis Kidney Failure, Chronic - etiology Kidney Failure, Chronic - genetics Kidney Failure, Chronic - mortality Kidneys Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Mortality Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Polymorphism Polymorphism, Single Nucleotide - physiology Prognosis Renal failure Survival Analysis Urinary system involvement in other diseases. Miscellaneous |
| title | polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T23%3A48%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=polymorphism%20in%20the%20gene%20encoding%20carnosinase%20(CNDP1)%20as%20a%20predictor%20of%20mortality%20and%20progression%20from%20nephropathy%20to%20end-stage%20renal%20disease%20in%20type%201%20diabetes%20mellitus&rft.jtitle=Diabetologia&rft.au=Alkhalaf,%20A&rft.date=2010-12-01&rft.volume=53&rft.issue=12&rft.spage=2562&rft.epage=2568&rft.pages=2562-2568&rft.issn=0012-186X&rft.eissn=1432-0428&rft_id=info:doi/10.1007/s00125-010-1863-0&rft_dat=%3Cproquest_pubme%3E954596893%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=807500178&rft_id=info:pmid/20711718&rfr_iscdi=true |