Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy

Aims/hypothesis Upregulation of the functional beta cell mass is required to match the physiological demands of mother and fetus during pregnancy. This increase is dependent on placental lactogens (PLs) and prolactin receptors, but the mechanisms underlying these events are only partially understood...

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Veröffentlicht in:	Diabetologia 2010-12, Vol.53 (12), p.2589-2599
Hauptverfasser:	Schraenen, A, Lemaire, K, de Faudeur, G, Hendrickx, N, Granvik, M, Van Lommel, L, Mallet, J, Vodjdani, G, Gilon, P, Binart, N, in't Veld, P, Schuit, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cell heterogeneity Biological and medical sciences Biology Biosynthesis Cells, Cultured choriomammotropin Diabetes. Impaired glucose tolerance Embryo, Mammalian Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymes Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fetuses Gene expression Gene Expression Regulation, Enzymologic - drug effects Gestational Age Human Physiology Insulin-Secreting Cells - classification Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Internal Medicine islets of Langerhans Kinases Laboratory animals Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Mice, Knockout Nervous system Placental Lactogen - pharmacology Placental Lactogen - physiology Pregnancy Pregnancy - metabolism Prolactin receptor Proteins Serotonin Serotonin - biosynthesis Stem cells Tph1 Tph2 Tryptophan hydroxylase Tryptophan Hydroxylase - genetics Tryptophan Hydroxylase - metabolism Up-Regulation - drug effects
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