New surface contacts formed upon reductive lysine methylation: Improving the probability of protein crystallization

Surface lysine methylation (SLM) is a technique for improving the rate of success of protein crystallization by chemically methylating lysine residues. The exact mechanism by which SLM enhances crystallization is still not clear. To study these mechanisms, and to analyze the conditions where SLM wil...

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Veröffentlicht in:	Protein science 2010-07, Vol.19 (7), p.1395-1404
Hauptverfasser:	Sledz, Pawel, Zheng, Heping, Murzyn, Krzysztof, Chruszcz, Maksymilian, Zimmerman, Matthew D., Chordia, Mahendra D., Joachimiak, Andrzej, Minor, Wladek
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallization data mining Databases, Protein intermolecular contacts Isoelectric Point Lysine - chemistry lysine methylation Methylation protein crystallization Proteins - chemistry surface entropy reduction Surface Properties Thermodynamics
Online-Zugang:	Volltext
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