small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease

Multiple sclerosis (MS) is a chronic, debilitating disease of the central nervous system (CNS) characterized by demyelination and axon loss. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) has been shown to be elevated in the cerebrospinal fluid of patients during relapses....

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Veröffentlicht in:	The FASEB journal 2010-11, Vol.24 (11), p.4459-4466
Hauptverfasser:	Kithcart, Aaron P, Cox, Gina M, Sielecki, Thais, Short, Abigail, Pruitt, James, Papenfuss, Tracey, Shawler, Todd, Gienapp, Ingrid, Satoskar, Abhay R, Whitacre, Caroline C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use blood‐brain barrier Brain - pathology Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - pathology experimental autoimmune encephalomyelitis Flow Cytometry Gene Deletion Gene Expression Regulation - drug effects Isoxazoles - pharmacology Isoxazoles - therapeutic use Macrophage Migration-Inhibitory Factors - antagonists & inhibitors Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Morpholines - pharmacology Morpholines - therapeutic use multiple sclerosis Research Communications Spinal Cord - pathology Vascular Cell Adhesion Molecule-1 - metabolism
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