QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains
The activity of mice in their home cage is influenced greatly by the cycle of light and dark. In addition, home-cage activity shows remarkable time-dependent changes that result in a prominent temporal pattern. The wild-derived mouse strain MSM/Ms (MSM) exhibits higher total activity in the home cag...
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| Veröffentlicht in: | Mammalian genome 2010-10, Vol.21 (9-10), p.477-485 |
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| creator | Nishi, Akinori Ishii, Ayako Takahashi, Aki Shiroishi, Toshihiko Koide, Tsuyoshi |
| description | The activity of mice in their home cage is influenced greatly by the cycle of light and dark. In addition, home-cage activity shows remarkable time-dependent changes that result in a prominent temporal pattern. The wild-derived mouse strain MSM/Ms (MSM) exhibits higher total activity in the home cage than does C57BL/6 (B6), a commonly used laboratory strain. In addition, there is a clear strain difference in the temporal pattern of home-cage activity. This study aimed to clarify the genetic basis of strain differences in the temporal pattern of home-cage activity between MSM and B6. Through the comparison of temporal patterns of home-cage activity between B6 and MSM, the pattern can be classified into five temporal components: (1) resting phase, (2) anticipation phase, (3) 1st phase, (4) 2nd phase, and (5) 3rd phase. To identify quantitative trait loci (QTLs) involved in these temporal components, we used consomic strains established from crosses between B6 and MSM. Five consomic strains, for Chrs 2T (telomere), 3, 4, 13, and 14, showed significantly higher total activity than B6. In contrast, the consomic strains of Chrs 6C (centromere), 7T, 9, 11, and 15 were less active than B6. This indicates that multigenic factors regulate the total activity. Further analysis showed an impact of QTLs on the temporal components of home-cage activity. The present data showed that each temporal component was regulated by different combinations of multigenic factors, with some overlap. These temporal component-related QTLs are important to understand fully the genetic mechanisms that underlie home-cage activity. |
| doi_str_mv | 10.1007/s00335-010-9289-z |
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In addition, home-cage activity shows remarkable time-dependent changes that result in a prominent temporal pattern. The wild-derived mouse strain MSM/Ms (MSM) exhibits higher total activity in the home cage than does C57BL/6 (B6), a commonly used laboratory strain. In addition, there is a clear strain difference in the temporal pattern of home-cage activity. This study aimed to clarify the genetic basis of strain differences in the temporal pattern of home-cage activity between MSM and B6. Through the comparison of temporal patterns of home-cage activity between B6 and MSM, the pattern can be classified into five temporal components: (1) resting phase, (2) anticipation phase, (3) 1st phase, (4) 2nd phase, and (5) 3rd phase. To identify quantitative trait loci (QTLs) involved in these temporal components, we used consomic strains established from crosses between B6 and MSM. Five consomic strains, for Chrs 2T (telomere), 3, 4, 13, and 14, showed significantly higher total activity than B6. In contrast, the consomic strains of Chrs 6C (centromere), 7T, 9, 11, and 15 were less active than B6. This indicates that multigenic factors regulate the total activity. Further analysis showed an impact of QTLs on the temporal components of home-cage activity. The present data showed that each temporal component was regulated by different combinations of multigenic factors, with some overlap. These temporal component-related QTLs are important to understand fully the genetic mechanisms that underlie home-cage activity.</description><identifier>ISSN: 0938-8990</identifier><identifier>EISSN: 1432-1777</identifier><identifier>DOI: 10.1007/s00335-010-9289-z</identifier><identifier>PMID: 20886216</identifier><language>eng</language><publisher>New York: New York : Springer-Verlag</publisher><subject>Animal Genetics and Genomics ; Animals ; Behavior, Animal ; Biomedical and Life Sciences ; Causality ; Cell Biology ; Chromosome Mapping ; Circadian Clocks - genetics ; Crosses, Genetic ; Human Genetics ; Life Sciences ; Matched-Pair Analysis ; Mice ; Mice, Congenic - genetics ; Mice, Inbred C57BL - genetics ; Mice, Inbred Strains - genetics ; Motor Activity - genetics ; Physical Exertion ; Quantitative Trait Loci - genetics</subject><ispartof>Mammalian genome, 2010-10, Vol.21 (9-10), p.477-485</ispartof><rights>The Author(s) 2010</rights><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-b97d3b9a5eb5d1112f10b0f7cf836995ccdd5e6f6dd83086cdd9ea965176c9b13</citedby><cites>FETCH-LOGICAL-c590t-b97d3b9a5eb5d1112f10b0f7cf836995ccdd5e6f6dd83086cdd9ea965176c9b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00335-010-9289-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00335-010-9289-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20886216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishi, Akinori</creatorcontrib><creatorcontrib>Ishii, Ayako</creatorcontrib><creatorcontrib>Takahashi, Aki</creatorcontrib><creatorcontrib>Shiroishi, Toshihiko</creatorcontrib><creatorcontrib>Koide, Tsuyoshi</creatorcontrib><title>QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains</title><title>Mammalian genome</title><addtitle>Mamm Genome</addtitle><addtitle>Mamm Genome</addtitle><description>The activity of mice in their home cage is influenced greatly by the cycle of light and dark. In addition, home-cage activity shows remarkable time-dependent changes that result in a prominent temporal pattern. The wild-derived mouse strain MSM/Ms (MSM) exhibits higher total activity in the home cage than does C57BL/6 (B6), a commonly used laboratory strain. In addition, there is a clear strain difference in the temporal pattern of home-cage activity. This study aimed to clarify the genetic basis of strain differences in the temporal pattern of home-cage activity between MSM and B6. Through the comparison of temporal patterns of home-cage activity between B6 and MSM, the pattern can be classified into five temporal components: (1) resting phase, (2) anticipation phase, (3) 1st phase, (4) 2nd phase, and (5) 3rd phase. To identify quantitative trait loci (QTLs) involved in these temporal components, we used consomic strains established from crosses between B6 and MSM. Five consomic strains, for Chrs 2T (telomere), 3, 4, 13, and 14, showed significantly higher total activity than B6. In contrast, the consomic strains of Chrs 6C (centromere), 7T, 9, 11, and 15 were less active than B6. This indicates that multigenic factors regulate the total activity. Further analysis showed an impact of QTLs on the temporal components of home-cage activity. The present data showed that each temporal component was regulated by different combinations of multigenic factors, with some overlap. These temporal component-related QTLs are important to understand fully the genetic mechanisms that underlie home-cage activity.</description><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Biomedical and Life Sciences</subject><subject>Causality</subject><subject>Cell Biology</subject><subject>Chromosome Mapping</subject><subject>Circadian Clocks - genetics</subject><subject>Crosses, Genetic</subject><subject>Human Genetics</subject><subject>Life Sciences</subject><subject>Matched-Pair Analysis</subject><subject>Mice</subject><subject>Mice, Congenic - genetics</subject><subject>Mice, Inbred C57BL - genetics</subject><subject>Mice, Inbred Strains - genetics</subject><subject>Motor Activity - genetics</subject><subject>Physical Exertion</subject><subject>Quantitative Trait Loci - genetics</subject><issn>0938-8990</issn><issn>1432-1777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU9v1DAQxS0EokvhA3CBiAun0LG9sT0XJKj4U2krBG3PluM4qaskbu2k0vbT41VKS3uAk23Nb97M8yPkNYUPFEAeJADOqxIolMgUljdPyIquOSuplPIpWQFyVSpE2CMvUroAoFJQ-ZzsMVBKMCpW5NfP001hRtNvk09FaIvBmTRHt9zDnFxxHgZXWtO5wtjJX_tpW8zJj13xWRwcnxwXNowpDN4WaYrGj-kledaaPrlXt-c-Ofv65fTwe7n58e3o8NOmtBXCVNYoG16jqVxdNZRS1lKooZW2VVwgVtY2TeVEK5pGcVAiP9EZFFU2YbGmfJ98XHQv53pwjXVjnt_ry-gHE7c6GK8fVkZ_rrtwrRnKNUXMAu9vBWK4ml2a9OCTdX1vRpeda1UJKVBJ9l9SCiZURXGdyXePyIswx_y_WQ7kWkkpdhBdIBtDStG1d0tT0Ltk9ZKszsnqXbL6Jve8-dvtXcefKDPAFiDl0ti5eD_5X6pvl6bWBG266JM-O2FAOVAEiQr4b4cMuK8</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Nishi, Akinori</creator><creator>Ishii, Ayako</creator><creator>Takahashi, Aki</creator><creator>Shiroishi, Toshihiko</creator><creator>Koide, Tsuyoshi</creator><general>New York : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201010</creationdate><title>QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains</title><author>Nishi, Akinori ; 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In addition, home-cage activity shows remarkable time-dependent changes that result in a prominent temporal pattern. The wild-derived mouse strain MSM/Ms (MSM) exhibits higher total activity in the home cage than does C57BL/6 (B6), a commonly used laboratory strain. In addition, there is a clear strain difference in the temporal pattern of home-cage activity. This study aimed to clarify the genetic basis of strain differences in the temporal pattern of home-cage activity between MSM and B6. Through the comparison of temporal patterns of home-cage activity between B6 and MSM, the pattern can be classified into five temporal components: (1) resting phase, (2) anticipation phase, (3) 1st phase, (4) 2nd phase, and (5) 3rd phase. To identify quantitative trait loci (QTLs) involved in these temporal components, we used consomic strains established from crosses between B6 and MSM. Five consomic strains, for Chrs 2T (telomere), 3, 4, 13, and 14, showed significantly higher total activity than B6. In contrast, the consomic strains of Chrs 6C (centromere), 7T, 9, 11, and 15 were less active than B6. This indicates that multigenic factors regulate the total activity. Further analysis showed an impact of QTLs on the temporal components of home-cage activity. The present data showed that each temporal component was regulated by different combinations of multigenic factors, with some overlap. These temporal component-related QTLs are important to understand fully the genetic mechanisms that underlie home-cage activity.</abstract><cop>New York</cop><pub>New York : Springer-Verlag</pub><pmid>20886216</pmid><doi>10.1007/s00335-010-9289-z</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal Genetics and Genomics Animals Behavior, Animal Biomedical and Life Sciences Causality Cell Biology Chromosome Mapping Circadian Clocks - genetics Crosses, Genetic Human Genetics Life Sciences Matched-Pair Analysis Mice Mice, Congenic - genetics Mice, Inbred C57BL - genetics Mice, Inbred Strains - genetics Motor Activity - genetics Physical Exertion Quantitative Trait Loci - genetics |
| title | QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains |
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