Langerhan's cell histiocytosis: A single institutional experience
Langerhans cell histiocytosis (LCH) is a disease that primarily affects bone but can be associated with a clinical spectrum that ranges from a solitary bone lesion with a favorable natural history to a multisystem, life-threatening disease process. We analyzed our single institutional experience of...
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| Veröffentlicht in: | Indian journal of medical and paediatric oncology 2010-04, Vol.31 (2), p.51-53 |
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| container_title | Indian journal of medical and paediatric oncology |
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| creator | Singh, Tejinder Satheesh, C T Appaji, L Aruna Kumari, B S Mamatha, H S Giri, G V Rama Rao, Clementina |
| description | Langerhans cell histiocytosis (LCH) is a disease that primarily affects bone but can be associated with a clinical spectrum that ranges from a solitary bone lesion with a favorable natural history to a multisystem, life-threatening disease process.
We analyzed our single institutional experience of managing children with LCH.
A total of 40 children of LCH, managed in tertiary cancer center in South India in the period from 2001 to 2005, were evaluated retrospectively.
Clinicopathological features, laboratory findings, treatment modalities and long-term outcome were analyzed.
Children were aged between 2 months and 12 years, with a mean of 3 years. Majority of the children were below 5 years of age. Group B constituted a bulk of children. Disseminated cases were less (five patients). Liver function dysfunction was seen in four (10%) children. Pulmonary interstitial infiltrates were seen in two (5%) cases. Diabetes insipidus manifested in three patients. There was one death.
A better understanding of the etiology and pathogenesis of LCH will result in more directed and efficacious treatment regimens. |
| doi_str_mv | 10.4103/0971-5851.71655 |
| format | Article |
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We analyzed our single institutional experience of managing children with LCH.
A total of 40 children of LCH, managed in tertiary cancer center in South India in the period from 2001 to 2005, were evaluated retrospectively.
Clinicopathological features, laboratory findings, treatment modalities and long-term outcome were analyzed.
Children were aged between 2 months and 12 years, with a mean of 3 years. Majority of the children were below 5 years of age. Group B constituted a bulk of children. Disseminated cases were less (five patients). Liver function dysfunction was seen in four (10%) children. Pulmonary interstitial infiltrates were seen in two (5%) cases. Diabetes insipidus manifested in three patients. There was one death.
A better understanding of the etiology and pathogenesis of LCH will result in more directed and efficacious treatment regimens.</description><identifier>ISSN: 0971-5851</identifier><identifier>EISSN: 0975-2129</identifier><identifier>DOI: 10.4103/0971-5851.71655</identifier><identifier>PMID: 21209764</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Adenosine triphosphatase ; Bone marrow ; Cancer ; Care and treatment ; Chemotherapy ; Diabetes ; Diagnosis ; Drug therapy ; Growth hormones ; Health aspects ; Langerhans-cell histiocytosis ; Original ; Prognosis</subject><ispartof>Indian journal of medical and paediatric oncology, 2010-04, Vol.31 (2), p.51-53</ispartof><rights>COPYRIGHT 2010 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Feb 2010</rights><rights>Indian Journal of Medical and Paediatric Oncology 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970934/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970934/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21209764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Tejinder</creatorcontrib><creatorcontrib>Satheesh, C T</creatorcontrib><creatorcontrib>Appaji, L</creatorcontrib><creatorcontrib>Aruna Kumari, B S</creatorcontrib><creatorcontrib>Mamatha, H S</creatorcontrib><creatorcontrib>Giri, G V</creatorcontrib><creatorcontrib>Rama Rao, Clementina</creatorcontrib><title>Langerhan's cell histiocytosis: A single institutional experience</title><title>Indian journal of medical and paediatric oncology</title><addtitle>Indian J Med Paediatr Oncol</addtitle><description>Langerhans cell histiocytosis (LCH) is a disease that primarily affects bone but can be associated with a clinical spectrum that ranges from a solitary bone lesion with a favorable natural history to a multisystem, life-threatening disease process.
We analyzed our single institutional experience of managing children with LCH.
A total of 40 children of LCH, managed in tertiary cancer center in South India in the period from 2001 to 2005, were evaluated retrospectively.
Clinicopathological features, laboratory findings, treatment modalities and long-term outcome were analyzed.
Children were aged between 2 months and 12 years, with a mean of 3 years. Majority of the children were below 5 years of age. Group B constituted a bulk of children. Disseminated cases were less (five patients). Liver function dysfunction was seen in four (10%) children. Pulmonary interstitial infiltrates were seen in two (5%) cases. Diabetes insipidus manifested in three patients. There was one death.
A better understanding of the etiology and pathogenesis of LCH will result in more directed and efficacious treatment regimens.</description><subject>Adenosine triphosphatase</subject><subject>Bone marrow</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Drug therapy</subject><subject>Growth hormones</subject><subject>Health aspects</subject><subject>Langerhans-cell histiocytosis</subject><subject>Original</subject><subject>Prognosis</subject><issn>0971-5851</issn><issn>0975-2129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkUFv1DAQhS1ERUvhzA1FINFTFju247gHpFUFtNJKXOBsOc4kceW1lzhB9N8z3S2oiyofbM375o3mmZA3jK4Eo_wj1YqVspFspVgt5TNyhhVZVqzSz_fvg3pKXuZ8SymXrG5ekFPUUavFGVlvbBxgGm28yIWDEIrR59kndzen7PNlsS6yj0OAwkeszwtq0YYCfu9g8hAdvCInvQ0ZXj_c5-THl8_fr67LzbevN1frTTlwTeeyV7ztGTTOUdULqWwlnLCgpGuZFW2vWsE7bTntENR9Ra1TVoDuBJVCdjU_J58Ovrul3ULnIM6TDWY3-a2d7kyy3hwr0Y9mSL9MpRXVXKDBxYPBlH4ukGez9fl-ZRshLdk0VaUpa_bku__I27RMuDZCdV1zdNQIvT9Agw1gfOwTTnX3lmZdcSRqDBip1RMUng623qUIvcf6UcOHRw0j2DCPOYV97vkYfPs4j39B_P1b_gdCoKTa</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Singh, Tejinder</creator><creator>Satheesh, C T</creator><creator>Appaji, L</creator><creator>Aruna Kumari, B S</creator><creator>Mamatha, H S</creator><creator>Giri, G V</creator><creator>Rama Rao, Clementina</creator><general>Medknow Publications and Media Pvt. 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We analyzed our single institutional experience of managing children with LCH.
A total of 40 children of LCH, managed in tertiary cancer center in South India in the period from 2001 to 2005, were evaluated retrospectively.
Clinicopathological features, laboratory findings, treatment modalities and long-term outcome were analyzed.
Children were aged between 2 months and 12 years, with a mean of 3 years. Majority of the children were below 5 years of age. Group B constituted a bulk of children. Disseminated cases were less (five patients). Liver function dysfunction was seen in four (10%) children. Pulmonary interstitial infiltrates were seen in two (5%) cases. Diabetes insipidus manifested in three patients. There was one death.
A better understanding of the etiology and pathogenesis of LCH will result in more directed and efficacious treatment regimens.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>21209764</pmid><doi>10.4103/0971-5851.71655</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Thieme Connect Journals Open Access |
| subjects | Adenosine triphosphatase Bone marrow Cancer Care and treatment Chemotherapy Diabetes Diagnosis Drug therapy Growth hormones Health aspects Langerhans-cell histiocytosis Original Prognosis |
| title | Langerhan's cell histiocytosis: A single institutional experience |
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