Basal plasma glucagon levels of man
The isolated perfused rat liver can serve as a bioassay system for glucagon, capable of detecting 10 mmug of this agent. Seven 15-ml plasma specimens obtained from different healthy volunteers after an overnight fast were assayed in this system; glucagon could not be detected in any of them, indicat...
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| Veröffentlicht in: | The Journal of clinical investigation 1967-05, Vol.46 (5), p.778-785 |
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| container_title | The Journal of clinical investigation |
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| creator | Sokal, J E Ezdinli, E Z |
| description | The isolated perfused rat liver can serve as a bioassay system for glucagon, capable of detecting 10 mmug of this agent. Seven 15-ml plasma specimens obtained from different healthy volunteers after an overnight fast were assayed in this system; glucagon could not be detected in any of them, indicating concentrations significantly below 0.67 mmug per ml in all subjects. The effects of administering small doses of glucagon to patients were consistent with these results; imposition of increments to plasma glucagon concentration below 1 mmug per ml induced distinct and sustained increases in blood glucose. Observations of the biologic effects of glucagon, together with data on the rate of its inactivation by the liver, suggest that the basal concentration of this hormone in peripheral plasma probably does not exceed 0.1 mmug per ml. |
| doi_str_mv | 10.1172/JCI105578 |
| format | Article |
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Seven 15-ml plasma specimens obtained from different healthy volunteers after an overnight fast were assayed in this system; glucagon could not be detected in any of them, indicating concentrations significantly below 0.67 mmug per ml in all subjects. The effects of administering small doses of glucagon to patients were consistent with these results; imposition of increments to plasma glucagon concentration below 1 mmug per ml induced distinct and sustained increases in blood glucose. Observations of the biologic effects of glucagon, together with data on the rate of its inactivation by the liver, suggest that the basal concentration of this hormone in peripheral plasma probably does not exceed 0.1 mmug per ml.</description><identifier>ISSN: 0021-9738</identifier><identifier>DOI: 10.1172/JCI105578</identifier><identifier>PMID: 6025482</identifier><language>eng</language><publisher>United States</publisher><subject>Blood Glucose - metabolism ; Glucagon - blood ; Glucagon - pharmacology ; Glucose - metabolism ; Humans ; Hypoglycemia - drug therapy ; Liver - enzymology ; Liver - metabolism ; Phosphotransferases</subject><ispartof>The Journal of clinical investigation, 1967-05, Vol.46 (5), p.778-785</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-5ebe3b62ecdd0eb9b335be0bb71df661bcdb1aa5cc396d4c3dfb003fee8857ea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC297080/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC297080/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6025482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sokal, J E</creatorcontrib><creatorcontrib>Ezdinli, E Z</creatorcontrib><title>Basal plasma glucagon levels of man</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>The isolated perfused rat liver can serve as a bioassay system for glucagon, capable of detecting 10 mmug of this agent. Seven 15-ml plasma specimens obtained from different healthy volunteers after an overnight fast were assayed in this system; glucagon could not be detected in any of them, indicating concentrations significantly below 0.67 mmug per ml in all subjects. The effects of administering small doses of glucagon to patients were consistent with these results; imposition of increments to plasma glucagon concentration below 1 mmug per ml induced distinct and sustained increases in blood glucose. Observations of the biologic effects of glucagon, together with data on the rate of its inactivation by the liver, suggest that the basal concentration of this hormone in peripheral plasma probably does not exceed 0.1 mmug per ml.</description><subject>Blood Glucose - metabolism</subject><subject>Glucagon - blood</subject><subject>Glucagon - pharmacology</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Hypoglycemia - drug therapy</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Phosphotransferases</subject><issn>0021-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkD1PwzAQhj2ASikM_ACkSEhIDIFzHCfOwAAVH0WVWGC2zvalBDlJiZtK_HuCWkUw3XDPex8PY2ccrjnPk5uX-YKDlLk6YFOAhMdFLtQROw7hE4CnqUwnbJJBIlOVTNnFPQb00dpjqDFa-d7iqm0iT1vyIWrLqMbmhB2W6AOd7uuMvT8-vM2f4-Xr02J-t4ytyIpNLMmQMFlC1jkgUxghpCEwJueuzDJurDMcUVorisylVrjSAIiSSCmZE4oZu93NXfemJmep2XTo9bqrauy-dYuV_t9pqg-9arc6KXJQMOQv9_mu_eopbHRdBUveY0NtH7QanlfAiwG82oG2a0PoqBx3cNC_EvUocWDP_x41knuD4gepxW-3</recordid><startdate>19670501</startdate><enddate>19670501</enddate><creator>Sokal, J E</creator><creator>Ezdinli, E Z</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19670501</creationdate><title>Basal plasma glucagon levels of man</title><author>Sokal, J E ; Ezdinli, E Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-5ebe3b62ecdd0eb9b335be0bb71df661bcdb1aa5cc396d4c3dfb003fee8857ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Blood Glucose - metabolism</topic><topic>Glucagon - blood</topic><topic>Glucagon - pharmacology</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Hypoglycemia - drug therapy</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Phosphotransferases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sokal, J E</creatorcontrib><creatorcontrib>Ezdinli, E Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sokal, J E</au><au>Ezdinli, E Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basal plasma glucagon levels of man</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>1967-05-01</date><risdate>1967</risdate><volume>46</volume><issue>5</issue><spage>778</spage><epage>785</epage><pages>778-785</pages><issn>0021-9738</issn><abstract>The isolated perfused rat liver can serve as a bioassay system for glucagon, capable of detecting 10 mmug of this agent. Seven 15-ml plasma specimens obtained from different healthy volunteers after an overnight fast were assayed in this system; glucagon could not be detected in any of them, indicating concentrations significantly below 0.67 mmug per ml in all subjects. The effects of administering small doses of glucagon to patients were consistent with these results; imposition of increments to plasma glucagon concentration below 1 mmug per ml induced distinct and sustained increases in blood glucose. Observations of the biologic effects of glucagon, together with data on the rate of its inactivation by the liver, suggest that the basal concentration of this hormone in peripheral plasma probably does not exceed 0.1 mmug per ml.</abstract><cop>United States</cop><pmid>6025482</pmid><doi>10.1172/JCI105578</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of clinical investigation, 1967-05, Vol.46 (5), p.778-785 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Blood Glucose - metabolism Glucagon - blood Glucagon - pharmacology Glucose - metabolism Humans Hypoglycemia - drug therapy Liver - enzymology Liver - metabolism Phosphotransferases |
| title | Basal plasma glucagon levels of man |
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