Zoledronic Acid Reduces Bone Loss and Tumor Growth in an Orthotopic Xenograft Model of Osteolytic Oral Squamous Cell Carcinoma

Squamous cell carcinoma (SCC) is the most common form of oral cancer. Destruction and invasion of mandibular and maxillary bone frequently occurs and contributes to morbidity and mortality. We hypothesized that the bisphosphonate drug zoledronic acid (ZOL) would inhibit tumor-induced osteolysis and...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-11, Vol.70 (21), p.8607-8616
Hauptverfasser:	MARTIN, Chelsea K, WERBECK, Jillian L, THUDI, Nanda K, LANIGAN, Lisa G, WOLFE, Tobie D, TORIBIO, Ramiro E, ROSOL, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase Animals Antineoplastic agents Biological and medical sciences Bone Density Conservation Agents - therapeutic use Bone Resorption - metabolism Bone Resorption - pathology Bone Resorption - prevention & control Calcium - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - prevention & control Cats Diphosphonates - therapeutic use Disease Models, Animal Diseases of the osteoarticular system Imidazoles - therapeutic use Isoenzymes Luciferases - metabolism Male Medical sciences Mice Mice, Nude Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Mouth Neoplasms - prevention & control Osteoclasts - cytology Osteoclasts - drug effects Osteolysis - metabolism Osteolysis - pathology Osteolysis - prevention & control Osteoporosis. Osteomalacia. Paget disease Pharmacology. Drug treatments Tartrate-Resistant Acid Phosphatase Transplantation, Heterologous Tumors Tumors of striated muscle and skeleton X-Ray Microtomography Zoledronic Acid
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