Identification of potential protein interactors of Lrrk2

Abstract Pathogenic substitutions in the Lrrk2 protein have been shown to be an important cause of both familial and sporadic parkinsonism. The molecular pathway involved in Lrrk2 dopaminergic neuron degeneration remains elusive. Employing a combination of Lrrk2-mediated protein precipitation and ta...

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Veröffentlicht in:	Parkinsonism & related disorders 2007-10, Vol.13 (7), p.382-385
Hauptverfasser:	Dächsel, Justus C, Taylor, Julie P, Mok, Su San, Ross, Owen A, Hinkle, Kelly M, Bailey, Rachel M, Hines, Jacob H, Szutu, Jennifer, Madden, Benjamin, Petrucelli, Leonard, Farrer, Matthew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Transformed Humans Immunoprecipitation - methods Interactors Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Lrrk2 Mass Spectrometry - methods Molecular Weight Neurology Protein-Serine-Threonine Kinases - metabolism Proteins - isolation & purification Proteins - metabolism Tandem mass spectrometry
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