Circadian and Homeostatic Regulation of Structural Synaptic Plasticity in Hypocretin Neurons

Neurons exhibit rhythmic activity that ultimately affects behavior such as sleep. In living zebrafish larvae, we used time-lapse two-photon imaging of the presynaptic marker synaptophysin in hypocretin/orexin (HCRT) neurons to determine the dynamics of synaptic modifications during the day and night...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2010-10, Vol.68 (1), p.87-98
Hauptverfasser:	Appelbaum, Lior, Wang, Gordon, Yokogawa, Tohei, Skariah, Gemini M., Smith, Stephen J., Mourrain, Philippe, Mignot, Emmanuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Animals Animals, Genetically Modified Axons - metabolism Behavior Behavior, Animal Brain - cytology Brain - growth & development Brain research C-Reactive Protein - genetics C-Reactive Protein - metabolism Circadian rhythm Circadian Rhythm - genetics Circadian Rhythm - physiology Danio rerio Endocrine system Experiments Freshwater Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - genetics Green Fluorescent Proteins - genetics Homeostasis - genetics Homeostasis - physiology Humans Hypotheses In Vitro Techniques Intracellular Signaling Peptides and Proteins - metabolism Larva Light Melatonin - pharmacology Microscopy Microscopy, Confocal Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neurons Neurons - cytology Neurons - physiology Neuropeptides - metabolism Orexins Pineal Gland - growth & development Pineal Gland - metabolism Proteins Rodents Synapses - genetics Synapses - physiology Synaptophysin - metabolism Vertebrates Zebrafish
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