Role of cytochrome P-450 in reperfusion injury of the rabbit lung

Reactive oxygen species are a major cause of damage occurring in ischemic tissue after reperfusion. During reperfusion transitional metals such as iron are required for reactive oxygen species to mediate their major toxic effects. Xanthine oxidase is an important source of reactive oxygen species du...

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Veröffentlicht in:	The Journal of clinical investigation 1990-11, Vol.86 (5), p.1434-1441
Hauptverfasser:	GOKOL KRIS BYSANI, KENNEDY, T. P, NGUYET KY, RAO, N. V, BLAZE, C. A, HOLDAL, J. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Capillary Permeability - drug effects Cimetidine - pharmacology Cytochrome P-450 Enzyme System - metabolism Fundamental and applied biological sciences. Psychology Iron - metabolism Ischemia Lung - blood supply Lung - enzymology Lung - pathology Methoxsalen - pharmacology Piperonyl Butoxide - pharmacology Rabbits Reperfusion Injury - enzymology Superoxides - metabolism Thiobarbiturates - metabolism Vertebrates: respiratory system
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