Fat Infiltration of Muscle, Diabetes, and Clinical Fracture Risk in Older Adults
Context: Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture. Objective: We investigated whether fat infiltration of muscle, wh...
Gespeichert in:
| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2010-11, Vol.95 (11), p.E368-E372 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | E372 |
|---|---|
| container_issue | 11 |
| container_start_page | E368 |
| container_title | The journal of clinical endocrinology and metabolism |
| container_volume | 95 |
| creator | Schafer, Anne L Vittinghoff, Eric Lang, Thomas F Sellmeyer, Deborah E Harris, Tamara B Kanaya, Alka M Strotmeyer, Elsa S Cawthon, Peggy M Cummings, Steven R Tylavsky, Frances A Scherzinger, Ann L Schwartz, Ann V |
| description | Context: Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture.
Objective: We investigated whether fat infiltration of muscle, which is greater in diabetic adults, is associated with all clinical fracture and whether it accounts for the increased fracture risk in those with diabetes.
Design, Setting, and Participants: Data were analyzed from the Health, Aging, and Body Composition Study, a cohort of community-dwelling adults aged 70–79 yr. Glucose metabolism status and x-ray attenuation of thigh muscle were determined at baseline for 2762 participants.
Main Outcome Measures: During a mean 8.2 ± 2.3 yr follow-up, 331 participants reported at least one clinical fracture.
Results: Fat infiltration of muscle was higher in those with diabetes or impaired glucose metabolism than in those with normal glucose metabolism (P < 0.001). Fat infiltration of muscle was independently associated with a 19% increased risk of incident clinical fracture (multivariate hazard ratio = 1.19; 95% confidence interval = 1.04–1.36); this association did not differ across glucose metabolism groups (P for interaction = 0.65). As previously reported, diabetes was associated with a greater fracture risk compared with normal glucose metabolism (hazard ratio = 1.42; 95% confidence interval = 1.07–1.89) after adjustment for bone mineral density, but further adjustment for fat infiltration of muscle did not attenuate this association.
Conclusions: Fat infiltration of muscle predicts clinical fracture in older adults. Although fat infiltration of muscle is higher among those with diabetes, it does not account for their increased fracture risk.
Fat infiltration of muscle predicts clinical fracture in older adults; although fat infiltration of muscle is higher among those with diabetes, it does not account for their increased fracture risk. |
| doi_str_mv | 10.1210/jc.2010-0780 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2968723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>799786756</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-ac86817578503d38306e4cf70c46660dd4c023c7fbb4200d41589e15d2d6f1dc3</originalsourceid><addsrcrecordid>eNptkc1LHDEYh0NpqVvbW88lt1529M3HJJmLIKvbCopSWugtZJNMmzWbrMmM4H_vLGtFoaf38D4878cPoc8EjgglcLy2RxQINCAVvEEz0vG2kaSTb9EMgJKmk_T3AfpQ6xqAcN6y9-iAghAKmJyhm6UZ8EXqQxyKGUJOOPf4aqw2-jk-C2blB1_n2CSHFzGkYE3Ey2LsMBaPf4R6i0PC19H5gk_dGIf6Eb3rTaz-01M9RL-W5z8X35vL628Xi9PLxvKODY2xSigiW6laYI4pBsJz20uwXAgBznELlFnZr1acAjhOWtV50jrqRE-cZYfoZO_djquNd9an6YCotyVsTHnQ2QT9upPCX_0n32vaCSUpmwRfnwQl342-DnoTqvUxmuTzWLXsOqmEbMVEzvekLbnW4vvnKQT0LgO9tnqXgd5lMOFfXm72DP97-gSwPeCTy7aE5LfF16rXeSxp-tn_tY9w1pKk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>799786756</pqid></control><display><type>article</type><title>Fat Infiltration of Muscle, Diabetes, and Clinical Fracture Risk in Older Adults</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Schafer, Anne L ; Vittinghoff, Eric ; Lang, Thomas F ; Sellmeyer, Deborah E ; Harris, Tamara B ; Kanaya, Alka M ; Strotmeyer, Elsa S ; Cawthon, Peggy M ; Cummings, Steven R ; Tylavsky, Frances A ; Scherzinger, Ann L ; Schwartz, Ann V</creator><creatorcontrib>Schafer, Anne L ; Vittinghoff, Eric ; Lang, Thomas F ; Sellmeyer, Deborah E ; Harris, Tamara B ; Kanaya, Alka M ; Strotmeyer, Elsa S ; Cawthon, Peggy M ; Cummings, Steven R ; Tylavsky, Frances A ; Scherzinger, Ann L ; Schwartz, Ann V ; Health, Aging, and Body Composition (Health ABC) Study</creatorcontrib><description>Context: Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture.
Objective: We investigated whether fat infiltration of muscle, which is greater in diabetic adults, is associated with all clinical fracture and whether it accounts for the increased fracture risk in those with diabetes.
Design, Setting, and Participants: Data were analyzed from the Health, Aging, and Body Composition Study, a cohort of community-dwelling adults aged 70–79 yr. Glucose metabolism status and x-ray attenuation of thigh muscle were determined at baseline for 2762 participants.
Main Outcome Measures: During a mean 8.2 ± 2.3 yr follow-up, 331 participants reported at least one clinical fracture.
Results: Fat infiltration of muscle was higher in those with diabetes or impaired glucose metabolism than in those with normal glucose metabolism (P < 0.001). Fat infiltration of muscle was independently associated with a 19% increased risk of incident clinical fracture (multivariate hazard ratio = 1.19; 95% confidence interval = 1.04–1.36); this association did not differ across glucose metabolism groups (P for interaction = 0.65). As previously reported, diabetes was associated with a greater fracture risk compared with normal glucose metabolism (hazard ratio = 1.42; 95% confidence interval = 1.07–1.89) after adjustment for bone mineral density, but further adjustment for fat infiltration of muscle did not attenuate this association.
Conclusions: Fat infiltration of muscle predicts clinical fracture in older adults. Although fat infiltration of muscle is higher among those with diabetes, it does not account for their increased fracture risk.
Fat infiltration of muscle predicts clinical fracture in older adults; although fat infiltration of muscle is higher among those with diabetes, it does not account for their increased fracture risk.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2010-0780</identifier><identifier>PMID: 20668037</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Adiposity - physiology ; Aged ; Blood Glucose - metabolism ; Bone Density - physiology ; Chi-Square Distribution ; Diabetes Mellitus, Type 2 - physiopathology ; Female ; Fractures, Bone - metabolism ; Fractures, Bone - physiopathology ; Humans ; Male ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiopathology ; Original ; Risk ; Risk Factors</subject><ispartof>The journal of clinical endocrinology and metabolism, 2010-11, Vol.95 (11), p.E368-E372</ispartof><rights>Copyright © 2010 by The Endocrine Society 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-ac86817578503d38306e4cf70c46660dd4c023c7fbb4200d41589e15d2d6f1dc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20668037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schafer, Anne L</creatorcontrib><creatorcontrib>Vittinghoff, Eric</creatorcontrib><creatorcontrib>Lang, Thomas F</creatorcontrib><creatorcontrib>Sellmeyer, Deborah E</creatorcontrib><creatorcontrib>Harris, Tamara B</creatorcontrib><creatorcontrib>Kanaya, Alka M</creatorcontrib><creatorcontrib>Strotmeyer, Elsa S</creatorcontrib><creatorcontrib>Cawthon, Peggy M</creatorcontrib><creatorcontrib>Cummings, Steven R</creatorcontrib><creatorcontrib>Tylavsky, Frances A</creatorcontrib><creatorcontrib>Scherzinger, Ann L</creatorcontrib><creatorcontrib>Schwartz, Ann V</creatorcontrib><creatorcontrib>Health, Aging, and Body Composition (Health ABC) Study</creatorcontrib><title>Fat Infiltration of Muscle, Diabetes, and Clinical Fracture Risk in Older Adults</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context: Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture.
Objective: We investigated whether fat infiltration of muscle, which is greater in diabetic adults, is associated with all clinical fracture and whether it accounts for the increased fracture risk in those with diabetes.
Design, Setting, and Participants: Data were analyzed from the Health, Aging, and Body Composition Study, a cohort of community-dwelling adults aged 70–79 yr. Glucose metabolism status and x-ray attenuation of thigh muscle were determined at baseline for 2762 participants.
Main Outcome Measures: During a mean 8.2 ± 2.3 yr follow-up, 331 participants reported at least one clinical fracture.
Results: Fat infiltration of muscle was higher in those with diabetes or impaired glucose metabolism than in those with normal glucose metabolism (P < 0.001). Fat infiltration of muscle was independently associated with a 19% increased risk of incident clinical fracture (multivariate hazard ratio = 1.19; 95% confidence interval = 1.04–1.36); this association did not differ across glucose metabolism groups (P for interaction = 0.65). As previously reported, diabetes was associated with a greater fracture risk compared with normal glucose metabolism (hazard ratio = 1.42; 95% confidence interval = 1.07–1.89) after adjustment for bone mineral density, but further adjustment for fat infiltration of muscle did not attenuate this association.
Conclusions: Fat infiltration of muscle predicts clinical fracture in older adults. Although fat infiltration of muscle is higher among those with diabetes, it does not account for their increased fracture risk.
Fat infiltration of muscle predicts clinical fracture in older adults; although fat infiltration of muscle is higher among those with diabetes, it does not account for their increased fracture risk.</description><subject>Adiposity - physiology</subject><subject>Aged</subject><subject>Blood Glucose - metabolism</subject><subject>Bone Density - physiology</subject><subject>Chi-Square Distribution</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Female</subject><subject>Fractures, Bone - metabolism</subject><subject>Fractures, Bone - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Original</subject><subject>Risk</subject><subject>Risk Factors</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1LHDEYh0NpqVvbW88lt1529M3HJJmLIKvbCopSWugtZJNMmzWbrMmM4H_vLGtFoaf38D4878cPoc8EjgglcLy2RxQINCAVvEEz0vG2kaSTb9EMgJKmk_T3AfpQ6xqAcN6y9-iAghAKmJyhm6UZ8EXqQxyKGUJOOPf4aqw2-jk-C2blB1_n2CSHFzGkYE3Ey2LsMBaPf4R6i0PC19H5gk_dGIf6Eb3rTaz-01M9RL-W5z8X35vL628Xi9PLxvKODY2xSigiW6laYI4pBsJz20uwXAgBznELlFnZr1acAjhOWtV50jrqRE-cZYfoZO_djquNd9an6YCotyVsTHnQ2QT9upPCX_0n32vaCSUpmwRfnwQl342-DnoTqvUxmuTzWLXsOqmEbMVEzvekLbnW4vvnKQT0LgO9tnqXgd5lMOFfXm72DP97-gSwPeCTy7aE5LfF16rXeSxp-tn_tY9w1pKk</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Schafer, Anne L</creator><creator>Vittinghoff, Eric</creator><creator>Lang, Thomas F</creator><creator>Sellmeyer, Deborah E</creator><creator>Harris, Tamara B</creator><creator>Kanaya, Alka M</creator><creator>Strotmeyer, Elsa S</creator><creator>Cawthon, Peggy M</creator><creator>Cummings, Steven R</creator><creator>Tylavsky, Frances A</creator><creator>Scherzinger, Ann L</creator><creator>Schwartz, Ann V</creator><general>Endocrine Society</general><general>The Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101101</creationdate><title>Fat Infiltration of Muscle, Diabetes, and Clinical Fracture Risk in Older Adults</title><author>Schafer, Anne L ; Vittinghoff, Eric ; Lang, Thomas F ; Sellmeyer, Deborah E ; Harris, Tamara B ; Kanaya, Alka M ; Strotmeyer, Elsa S ; Cawthon, Peggy M ; Cummings, Steven R ; Tylavsky, Frances A ; Scherzinger, Ann L ; Schwartz, Ann V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-ac86817578503d38306e4cf70c46660dd4c023c7fbb4200d41589e15d2d6f1dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adiposity - physiology</topic><topic>Aged</topic><topic>Blood Glucose - metabolism</topic><topic>Bone Density - physiology</topic><topic>Chi-Square Distribution</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Female</topic><topic>Fractures, Bone - metabolism</topic><topic>Fractures, Bone - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Original</topic><topic>Risk</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schafer, Anne L</creatorcontrib><creatorcontrib>Vittinghoff, Eric</creatorcontrib><creatorcontrib>Lang, Thomas F</creatorcontrib><creatorcontrib>Sellmeyer, Deborah E</creatorcontrib><creatorcontrib>Harris, Tamara B</creatorcontrib><creatorcontrib>Kanaya, Alka M</creatorcontrib><creatorcontrib>Strotmeyer, Elsa S</creatorcontrib><creatorcontrib>Cawthon, Peggy M</creatorcontrib><creatorcontrib>Cummings, Steven R</creatorcontrib><creatorcontrib>Tylavsky, Frances A</creatorcontrib><creatorcontrib>Scherzinger, Ann L</creatorcontrib><creatorcontrib>Schwartz, Ann V</creatorcontrib><creatorcontrib>Health, Aging, and Body Composition (Health ABC) Study</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schafer, Anne L</au><au>Vittinghoff, Eric</au><au>Lang, Thomas F</au><au>Sellmeyer, Deborah E</au><au>Harris, Tamara B</au><au>Kanaya, Alka M</au><au>Strotmeyer, Elsa S</au><au>Cawthon, Peggy M</au><au>Cummings, Steven R</au><au>Tylavsky, Frances A</au><au>Scherzinger, Ann L</au><au>Schwartz, Ann V</au><aucorp>Health, Aging, and Body Composition (Health ABC) Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fat Infiltration of Muscle, Diabetes, and Clinical Fracture Risk in Older Adults</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>95</volume><issue>11</issue><spage>E368</spage><epage>E372</epage><pages>E368-E372</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context: Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture.
Objective: We investigated whether fat infiltration of muscle, which is greater in diabetic adults, is associated with all clinical fracture and whether it accounts for the increased fracture risk in those with diabetes.
Design, Setting, and Participants: Data were analyzed from the Health, Aging, and Body Composition Study, a cohort of community-dwelling adults aged 70–79 yr. Glucose metabolism status and x-ray attenuation of thigh muscle were determined at baseline for 2762 participants.
Main Outcome Measures: During a mean 8.2 ± 2.3 yr follow-up, 331 participants reported at least one clinical fracture.
Results: Fat infiltration of muscle was higher in those with diabetes or impaired glucose metabolism than in those with normal glucose metabolism (P < 0.001). Fat infiltration of muscle was independently associated with a 19% increased risk of incident clinical fracture (multivariate hazard ratio = 1.19; 95% confidence interval = 1.04–1.36); this association did not differ across glucose metabolism groups (P for interaction = 0.65). As previously reported, diabetes was associated with a greater fracture risk compared with normal glucose metabolism (hazard ratio = 1.42; 95% confidence interval = 1.07–1.89) after adjustment for bone mineral density, but further adjustment for fat infiltration of muscle did not attenuate this association.
Conclusions: Fat infiltration of muscle predicts clinical fracture in older adults. Although fat infiltration of muscle is higher among those with diabetes, it does not account for their increased fracture risk.
Fat infiltration of muscle predicts clinical fracture in older adults; although fat infiltration of muscle is higher among those with diabetes, it does not account for their increased fracture risk.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>20668037</pmid><doi>10.1210/jc.2010-0780</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2010-11, Vol.95 (11), p.E368-E372 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2968723 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adiposity - physiology Aged Blood Glucose - metabolism Bone Density - physiology Chi-Square Distribution Diabetes Mellitus, Type 2 - physiopathology Female Fractures, Bone - metabolism Fractures, Bone - physiopathology Humans Male Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Original Risk Risk Factors |
| title | Fat Infiltration of Muscle, Diabetes, and Clinical Fracture Risk in Older Adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T22%3A36%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fat%20Infiltration%20of%20Muscle,%20Diabetes,%20and%20Clinical%20Fracture%20Risk%20in%20Older%20Adults&rft.jtitle=The%20journal%20of%20clinical%20endocrinology%20and%20metabolism&rft.au=Schafer,%20Anne%20L&rft.aucorp=Health,%20Aging,%20and%20Body%20Composition%20(Health%20ABC)%20Study&rft.date=2010-11-01&rft.volume=95&rft.issue=11&rft.spage=E368&rft.epage=E372&rft.pages=E368-E372&rft.issn=0021-972X&rft.eissn=1945-7197&rft_id=info:doi/10.1210/jc.2010-0780&rft_dat=%3Cproquest_pubme%3E799786756%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=799786756&rft_id=info:pmid/20668037&rfr_iscdi=true |