Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice

Two forms of X-chromosome inactivation (XCI) ensure the selective silencing of female sex chromosomes during mouse embryogenesis. Imprinted XCI begins with the detection of Xist RNA expression on the paternal X chromosome (Xp) at about the four-cell stage of embryonic development. In the embryonic t...

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Veröffentlicht in:	Nature (London) 2010-10, Vol.467 (7318), p.977-981
Hauptverfasser:	Bach, Ingolf, Shin, JongDae, Bossenz, Michael, Chung, Young, Ma, Hong, Byron, Meg, Taniguchi-Ishigaki, Naoko, Zhu, Xiaochun, Jiao, Baowei, Hall, Lisa L, Green, Michael R, Jones, Stephen N, Hermans-Borgmeyer, Irm, Lawrence, Jeanne B
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/532/2117 631/208 631/80/103 Abnormalities Animals Animals, Congenic Biological and medical sciences Blastocyst - metabolism Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Chromosomes Chromosomes, Mammalian - genetics Embryo Loss - genetics Embryonic development Embryonic growth stage Embryos Fathers Female Females Fundamental and applied biological sciences. Psychology Gene Silencing Genetic aspects Genomic Imprinting Humanities and Social Sciences Inactivation letter Male Males Mice Mice, Transgenic Molecular and cellular biology Mothers multidisciplinary Physiological aspects Proteins Repressor Proteins - deficiency Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Long Noncoding RNA, Untranslated - genetics Science Science (multidisciplinary) Stem cells Ubiquitin Ubiquitin-Protein Ligases X chromosome X Chromosome - genetics X Chromosome Inactivation - genetics
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