Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage

Objective: Osteopontin (OPN), a pleiotropic extracellular matrix glycoprotein, has been reported to be protective against ischemic lesions, but effects of OPN on vascular functions have not been investigated. The aim of this study was to assess whether recombinant OPN (r‐OPN) could prevent cerebral...

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Veröffentlicht in:	Annals of neurology 2010-11, Vol.68 (5), p.650-660
Hauptverfasser:	Suzuki, Hidenori, Hasegawa, Yu, Chen, Wanqiu, Kanamaru, Kenji, Zhang, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Biological and medical sciences Cerebral Arteries - drug effects Cerebral Arteries - metabolism Cerebral Arteries - pathology Disease Models, Animal Drug Interactions Dual Specificity Phosphatase 1 - metabolism Injections, Intraventricular Male Medical sciences Neurology Oligopeptides - administration & dosage Osteopontin - administration & dosage Osteopontin - antagonists & inhibitors Rats Rats, Sprague-Dawley Recombinant Proteins - administration & dosage Recombinant Proteins - antagonists & inhibitors RNA, Small Interfering - administration & dosage Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - metabolism Subarachnoid Hemorrhage - pathology Up-Regulation Vascular diseases and vascular malformations of the nervous system Vasospasm, Intracranial - complications Vasospasm, Intracranial - metabolism Vasospasm, Intracranial - prevention & control
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