Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

Aurora B is a component of the chromosomal passenger complex (CPC) required for correct spindle-kinetochore attachments during chromosome segregation and for cytokinesis. The chromatin factors that recruit the CPC to centromeres are unknown, however. Here we show that phosphorylation of histone H3 t...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2010-10, Vol.330 (6001), p.231-235
Hauptverfasser:	Wang, Fangwei, Dai, Jun, Daum, John R., Niedzialkowska, Ewa, Banerjee, Budhaditya, Stukenberg, P. Todd, Gorbsky, Gary J., Higgins, Jonathan M. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Aurora Kinase B Aurora Kinases Biochemistry Biological and medical sciences Cell Cycle Proteins - metabolism Cell cycle, cell proliferation Cell division Cell Line Cell Line, Tumor Cell lines Cell physiology Centromere - metabolism Centromeres Chromatin Chromatin - metabolism Chromosomes Cytokinesis Fluorescent antibody techniques Fundamental and applied biological sciences. Psychology HeLa Cells Histones Histones - metabolism Humans Inhibitor of Apoptosis Proteins Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases Kinesin - metabolism Kinetochores - metabolism Microtubule-Associated Proteins - chemistry Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mitosis Molecular and cellular biology Mutation Phosphorylation Protein Binding Protein Interaction Domains and Motifs Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Recombinant Proteins - metabolism RNA Interference Spindle Apparatus - metabolism Swine Threonine - metabolism Xenopus
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