EphB-Mediated Degradation of the RhoA GEF Ephexin5 Relieves a Developmental Brake on Excitatory Synapse Formation

The mechanisms that promote excitatory synapse formation and maturation have been extensively studied. However, the molecular events that limit excitatory synapse development so that synapses form at the right time and place and in the correct numbers are less well understood. We have identified a R...

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Veröffentlicht in:	Cell 2010-10, Vol.143 (3), p.442-455
Hauptverfasser:	Margolis, Seth S., Salogiannis, John, Lipton, David M., Mandel-Brehm, Caleigh, Wills, Zachary P., Mardinly, Alan R., Hu, Linda, Greer, Paul L., Bikoff, Jay B., Ho, Hsin-Yi Henry, Soskis, Michael J., Sahin, Mustafa, Greenberg, Michael E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angelman Syndrome - metabolism Animals Autism Child Child Development Disorders, Pervasive - metabolism Dentate Gyrus - cytology Dentate Gyrus - metabolism Embryo, Mammalian - metabolism Gene Knockout Techniques Humans HUMDISEASE Mice MOLNEURO Rats Rats, Long-Evans Receptors, Eph Family - genetics rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Synapses - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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