Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa

The use of marrow stem cells to treat seven children with severe epidermolysis bullosa caused by loss-of-function mutations in COL7A, the gene encoding type VII collagen (C7), was examined. The investigators observed increases in C7 deposition, the presence of donor cells in the skin, and an amelior...

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Veröffentlicht in:	The New England journal of medicine 2010-08, Vol.363 (7), p.629-639
Hauptverfasser:	Wagner, John E, Ishida-Yamamoto, Akemi, McGrath, John A, Hordinsky, Maria, Keene, Douglas R, Woodley, David T, Chen, Mei, Riddle, Megan J, Osborn, Mark J, Lund, Troy, Dolan, Michelle, Blazar, Bruce R, Tolar, Jakub
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Bone marrow Bone Marrow Transplantation - adverse effects Chemotherapy Child Child, Preschool Collagen Type VII - genetics Collagen Type VII - immunology Collagen Type VII - metabolism Collagen Type VII - ultrastructure Epidermolysis Bullosa Dystrophica - genetics Epidermolysis Bullosa Dystrophica - pathology Epidermolysis Bullosa Dystrophica - therapy Female Fetal Blood - transplantation Genes, Recessive Graft Rejection Humans Male Microscopy, Electron, Transmission Mutation Ostomy Patients Reticulin - ultrastructure Skin Skin - metabolism Skin - pathology Skin - ultrastructure Stem cells Transplantation Chimera Transplantation Conditioning - adverse effects Transplantation, Homologous Transplants & implants
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