The Transcription Factor GATA-6 Regulates Pathological Cardiac Hypertrophy

RATIONALE:The transcriptional code that programs maladaptive cardiac hypertrophy involves the zinc finger–containing DNA binding factor GATA-4. The highly related transcription factor GATA-6 is also expressed in the adult heart, although its role in controlling the hypertrophic program is unknown. O...

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Veröffentlicht in:	Circulation research 2010-10, Vol.107 (8), p.1032-1040
Hauptverfasser:	van Berlo, Jop H, Elrod, John W, van den Hoogenhof, Maarten M.G, York, Allen J, Aronow, Bruce J, Duncan, Stephen A, Molkentin, Jeffery D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - physiology Cardiomegaly - genetics Cardiomegaly - pathology Cardiomegaly - physiopathology Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - pathology Cardiomyopathy, Dilated - physiopathology Cell Differentiation - genetics Fundamental and applied biological sciences. Psychology GATA4 Transcription Factor - metabolism GATA6 Transcription Factor - genetics GATA6 Transcription Factor - metabolism Gene Deletion Heart Failure - genetics Heart Failure - pathology Heart Failure - physiopathology Homeostasis - genetics Mice Mice, Transgenic Transcription, Genetic - physiology Vertebrates: cardiovascular system
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