Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism
The arcuate fasciculus is a white matter fiber bundle of great importance in language. In this study, diffusion tensor imaging (DTI) was used to infer white matter integrity in the arcuate fasciculi of a group of subjects with high-functioning autism and a control group matched for age, handedness,...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2010-07, Vol.51 (3), p.1117-1125 |
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| container_title | NeuroImage (Orlando, Fla.) |
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| creator | Fletcher, P. Thomas Whitaker, Ross T. Tao, Ran DuBray, Molly B. Froehlich, Alyson Ravichandran, Caitlin Alexander, Andrew L. Bigler, Erin D. Lange, Nicholas Lainhart, Janet E. |
| description | The arcuate fasciculus is a white matter fiber bundle of great importance in language. In this study, diffusion tensor imaging (DTI) was used to infer white matter integrity in the arcuate fasciculi of a group of subjects with high-functioning autism and a control group matched for age, handedness, IQ, and head size. The arcuate fasciculus for each subject was automatically extracted from the imaging data using a new volumetric DTI segmentation algorithm. The results showed a significant increase in mean diffusivity (MD) in the autism group, due mostly to an increase in the radial diffusivity (RD). A test of the lateralization of DTI measurements showed that both MD and fractional anisotropy (FA) were less lateralized in the autism group. These results suggest that white matter microstructure in the arcuate fasciculus is affected in autism and that the language specialization apparent in the left arcuate of healthy subjects is not as evident in autism, which may be related to poorer language functioning. |
| doi_str_mv | 10.1016/j.neuroimage.2010.01.083 |
| format | Article |
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Thomas ; Whitaker, Ross T. ; Tao, Ran ; DuBray, Molly B. ; Froehlich, Alyson ; Ravichandran, Caitlin ; Alexander, Andrew L. ; Bigler, Erin D. ; Lange, Nicholas ; Lainhart, Janet E.</creator><creatorcontrib>Fletcher, P. Thomas ; Whitaker, Ross T. ; Tao, Ran ; DuBray, Molly B. ; Froehlich, Alyson ; Ravichandran, Caitlin ; Alexander, Andrew L. ; Bigler, Erin D. ; Lange, Nicholas ; Lainhart, Janet E.</creatorcontrib><description>The arcuate fasciculus is a white matter fiber bundle of great importance in language. In this study, diffusion tensor imaging (DTI) was used to infer white matter integrity in the arcuate fasciculi of a group of subjects with high-functioning autism and a control group matched for age, handedness, IQ, and head size. The arcuate fasciculus for each subject was automatically extracted from the imaging data using a new volumetric DTI segmentation algorithm. The results showed a significant increase in mean diffusivity (MD) in the autism group, due mostly to an increase in the radial diffusivity (RD). A test of the lateralization of DTI measurements showed that both MD and fractional anisotropy (FA) were less lateralized in the autism group. These results suggest that white matter microstructure in the arcuate fasciculus is affected in autism and that the language specialization apparent in the left arcuate of healthy subjects is not as evident in autism, which may be related to poorer language functioning.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2010.01.083</identifier><identifier>PMID: 20132894</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Arcuate fasciculus ; Arcuate Nucleus of Hypothalamus - pathology ; Attention deficit hyperactivity disorder ; Autism ; Autistic Disorder - pathology ; Brain ; Child ; Diffusion tensor imaging ; Diffusion Tensor Imaging - methods ; Female ; Humans ; Male ; Nerve Fibers, Myelinated - pathology ; Neural Pathways - pathology ; Studies</subject><ispartof>NeuroImage (Orlando, Fla.), 2010-07, Vol.51 (3), p.1117-1125</ispartof><rights>2010 Elsevier Inc.</rights><rights>Copyright (c) 2010 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jul 1, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-f482a9f1adf698e2e79f5020bfaf894272dec03df35b9d809185a58925ebadf83</citedby><cites>FETCH-LOGICAL-c538t-f482a9f1adf698e2e79f5020bfaf894272dec03df35b9d809185a58925ebadf83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1506838238?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20132894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fletcher, P. Thomas</creatorcontrib><creatorcontrib>Whitaker, Ross T.</creatorcontrib><creatorcontrib>Tao, Ran</creatorcontrib><creatorcontrib>DuBray, Molly B.</creatorcontrib><creatorcontrib>Froehlich, Alyson</creatorcontrib><creatorcontrib>Ravichandran, Caitlin</creatorcontrib><creatorcontrib>Alexander, Andrew L.</creatorcontrib><creatorcontrib>Bigler, Erin D.</creatorcontrib><creatorcontrib>Lange, Nicholas</creatorcontrib><creatorcontrib>Lainhart, Janet E.</creatorcontrib><title>Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>The arcuate fasciculus is a white matter fiber bundle of great importance in language. In this study, diffusion tensor imaging (DTI) was used to infer white matter integrity in the arcuate fasciculi of a group of subjects with high-functioning autism and a control group matched for age, handedness, IQ, and head size. The arcuate fasciculus for each subject was automatically extracted from the imaging data using a new volumetric DTI segmentation algorithm. The results showed a significant increase in mean diffusivity (MD) in the autism group, due mostly to an increase in the radial diffusivity (RD). A test of the lateralization of DTI measurements showed that both MD and fractional anisotropy (FA) were less lateralized in the autism group. These results suggest that white matter microstructure in the arcuate fasciculus is affected in autism and that the language specialization apparent in the left arcuate of healthy subjects is not as evident in autism, which may be related to poorer language functioning.</description><subject>Adolescent</subject><subject>Arcuate fasciculus</subject><subject>Arcuate Nucleus of Hypothalamus - pathology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Autism</subject><subject>Autistic Disorder - pathology</subject><subject>Brain</subject><subject>Child</subject><subject>Diffusion tensor imaging</subject><subject>Diffusion Tensor Imaging - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>Neural Pathways - pathology</subject><subject>Studies</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNUctuEzEUtRCItoFfQJZYsJrgx3hib5CgAopUxAbWlsdznTia2MWPoP49HlLKYwMrW_Y5954HQpiSNSV0eLlfB6gp-oPZwpqR9kzomkj-AJ1TokSnxIY9XO6Cd5JSdYYuct4TQhTt5WN01iicSdWfo_GjtynmkqotNZkZ2xgC2OKPvtzi6HDZATbJVlMAO5Ott3WuGfuAzRRnyBZCyfibLzu889td52po7Bh82GJTi8-HJ-iRM3OGp3fnCn159_bz5VV3_en9h8vX150VXJbO9ZIZ5aiZ3KAkMNgoJwgjozOuSWUbNoElfHJcjGqSzYoURkjFBIyNI_kKvTrNvanjAaZFWDOkb1KLKd3qaLz-8yf4nd7Go2ZqGFTP24AXdwNS_FohF33wzd88mwCxZr3pheKMyf9Acq64VC3lFXr-F3IfawotB00FGSSXjC_S5Qm1dJETuHvVlOilcb3XvxrXS-OaUE1-SHn2u-t74s-KG-DNCQAt-6OHpFuJECxMPrWi9RT9v7d8B8MXxUM</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Fletcher, P. 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Thomas</au><au>Whitaker, Ross T.</au><au>Tao, Ran</au><au>DuBray, Molly B.</au><au>Froehlich, Alyson</au><au>Ravichandran, Caitlin</au><au>Alexander, Andrew L.</au><au>Bigler, Erin D.</au><au>Lange, Nicholas</au><au>Lainhart, Janet E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>51</volume><issue>3</issue><spage>1117</spage><epage>1125</epage><pages>1117-1125</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>The arcuate fasciculus is a white matter fiber bundle of great importance in language. In this study, diffusion tensor imaging (DTI) was used to infer white matter integrity in the arcuate fasciculi of a group of subjects with high-functioning autism and a control group matched for age, handedness, IQ, and head size. The arcuate fasciculus for each subject was automatically extracted from the imaging data using a new volumetric DTI segmentation algorithm. The results showed a significant increase in mean diffusivity (MD) in the autism group, due mostly to an increase in the radial diffusivity (RD). A test of the lateralization of DTI measurements showed that both MD and fractional anisotropy (FA) were less lateralized in the autism group. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Adolescent Arcuate fasciculus Arcuate Nucleus of Hypothalamus - pathology Attention deficit hyperactivity disorder Autism Autistic Disorder - pathology Brain Child Diffusion tensor imaging Diffusion Tensor Imaging - methods Female Humans Male Nerve Fibers, Myelinated - pathology Neural Pathways - pathology Studies |
| title | Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism |
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