Convergent donor and acceptor substrate utilization among kinase ribozymes

Accommodation of donor and acceptor substrates is critical to the catalysis of (thio)phosphoryl group transfer, but there has been no systematic study of donor nucleotide recognition by kinase ribozymes, and there is relatively little known about the structural requirements for phosphorylating inter...

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Veröffentlicht in:	Nucleic acids research 2010-10, Vol.38 (19), p.6785-6795
Hauptverfasser:	Biondi, Elisa, Nickens, David G, Warren, Samantha, Saran, Dayal, Burke, Donald H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Base Sequence Biocatalysis Catalysis Convergence Guanosine Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Kinetics Molecular Sequence Data Nucleic Acid Conformation Nucleotide analogs Nucleotides Phosphate Phosphorylation Phosphotransferases - chemistry Phosphotransferases - metabolism Protein structure Ribose Ribozymes RNA, Catalytic - chemistry RNA, Catalytic - metabolism Secondary structure Substrate Specificity Synthetic Biology and Chemistry
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