Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity

Although aging is a ubiquitous process that prevails in all organisms, the mechanisms governing both the rate of decline in functionality and the age of onset remain elusive. A profound constitutively upregulated cytoprotective response is commonly observed in naturally long-lived species and experi...

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Veröffentlicht in:	Integrative and comparative biology 2010-11, Vol.50 (5), p.829-843
Hauptverfasser:	Lewis, Kaitlyn N., Mele, James, Hayes, John D., Buffenstein, Rochelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - physiology Animals Antioxidants Autophagy Cell Survival - physiology Cytoprotection Cytoprotection - physiology Enzymes Gene expression Genes Longevity Longevity - physiology Metabolism Metabolism, Life History and Aging Mice NF-E2-Related Factor 2 - physiology Oxidative stress Proteins Signal transduction Signal Transduction - physiology Tissues Toxins Transcription factors Transcriptional regulatory elements
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