Development of an LC–MS/MS assay to determine plasma pharmacokinetics of the radioprotectant octadecyl thiophosphate (OTP) in monkeys

Octadecenyl thiophosphate (OTP), a synthetic analogue of the lysophospholipid growth factor lysophosphatidic acid (LPA), significantly reduces mortality following a lethal dose of LD 80/30 radiation exposure in a mouse model of whole-body irradiation. To facilitate dose scaling between species, we d...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2010-09, Vol.878 (26), p.2379-2383
Hauptverfasser:	Kosanam, Hari, Ma, Fei, He, Hui, Ramagiri, Suma, Gududuru, Veeresa, Tigyi, Gabor J., Van Rompay, Koen, Miller, Duane D., Yates, Charles R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogue Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Deuteration Fundamental and applied biological sciences. Psychology General pharmacology Ionization Liquid chromatography Liquid chromatography/tandem mass spectrometry (LC–MS/MS) Liquid-liquid extraction Lysophosphatidic acid (LPA) Mathematical models Medical sciences Monkeys Octadecenyl thiophosphate (OTP) Pharmacokinetics Pharmacology. Drug treatments Receiving
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