Ryanodine receptors: structure, expression, molecular details, and function in calcium release

Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum membrane and are responsible for the release of Ca(2+) from intracellular stores during excitation-contraction coupling in both cardiac and skeletal muscle. RyRs are the largest known ion channels (> 2MDa) and exist...

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Veröffentlicht in:	Cold Spring Harbor perspectives in biology 2010-11, Vol.2 (11), p.a003996-a003996
Hauptverfasser:	Lanner, Johanna T, Georgiou, Dimitra K, Joshi, Aditya D, Hamilton, Susan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Signaling Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Calmodulin - metabolism Calsequestrin - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Humans Models, Molecular Muscle, Skeletal - metabolism Myocardium - metabolism Ryanodine Receptor Calcium Release Channel - chemistry Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Tacrolimus Binding Protein 1A - metabolism
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