MRI measurements of carotid plaque in the atherosclerosis risk in communities (ARIC) study: Methods, reliability and descriptive statistics
Purpose: To measure carotid plaque components using MRI and estimate reliability in the population‐based Atherosclerosis Risk in Communities (ARIC) study. Materials and Methods: Contrast‐enhanced high‐resolution (0.51 × 0.58 × 2 mm3) MRI images were acquired through internal (ICA) and common carotid...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2010-02, Vol.31 (2), p.406-415 |
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| creator | Wasserman, Bruce A. Astor, Brad C. Sharrett, A. Richey Swingen, Cory Catellier, Diane |
| description | Purpose:
To measure carotid plaque components using MRI and estimate reliability in the population‐based Atherosclerosis Risk in Communities (ARIC) study.
Materials and Methods:
Contrast‐enhanced high‐resolution (0.51 × 0.58 × 2 mm3) MRI images were acquired through internal (ICA) and common carotid arteries (CCA) of 2066 ARIC participants at four sites. Sixty‐one exams were repeated and 164 pairs had repeated interpretations. Plaque component thicknesses, areas and volumes over eight slices (1.6‐cm segment) were measured. Intraplaque hemorrhage was recorded. Reliability was evaluated by intraclass correlations and κ statistics.
Results:
There were 1769 successful MRI exams (mean age 71 years; 57% females; 81% white; 19% African‐Americans). Repeat scan reliability was highest for CCA lumen area (0.94) and maximum wall thickness (0.89), ICA lumen area (0.89) and maximum wall thickness (0.77) and total wall volume (0.79), and lowest for small structures—core volume (0.30) and mean cap thickness (0.38). Overall reliability was primarily related to reader variability rather than scan acquisition. K's for presence of core, calcification and hemorrhage were fair to good. White men had the thickest plaques (average maximum ICA wall thickness = 2.3 mm) and the most cores (34%).
Conclusion:
The most important limiting factor for MRI measurements of plaque components is reader variability. Measurement error depends largely on the analyzed structure's size. J. Magn. Reson. Imaging 2010; 31: 406–415. © 2010 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.22043 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2963866</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733885425</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5233-88a338be8bfdcfe9684c202bdffe581cc6aade81bacc860545f7c2f39ec40bc13</originalsourceid><addsrcrecordid>eNp9kdtu1DAQhiNERUvhhgdAvuOgpjh2nDhcIJVVKYu6RS2nS8uxJ-y0OSy207LPwEvjsO0KbrgZjzTf_DOeP0meZPQwo5S9uuwcHjJGc34v2csEYykTsrgfcyp4mkla7iYPvb-klFZVLh4ku2zKuMj3kl-LiznpQPvRQQd98GRoiNFuCGjJqtU_RiDYk7AEomNwgzftFNETh_5qqpmh68YeA4Inz48u5rMXxIfRrl-TBYTlYP0BcdCirrHFsCa6t8SCNw5XAa8hsjqgD2j8o2Sn0a2Hx7fvfvLl3fHn2fv09OPJfHZ0mhrBOE-l1JzLGmTdWNNAVcjcMMpq2zQgZGZMobUFmdXaGFlQkYumNKzhFZic1ibj-8mbje5qrDuwJn7b6VatHHbardWgUf1b6XGpvg_XilUFl0URBZ7dCrghHsgH1aE30La6h2H0qoz7SZEzEcmXG9LEm3kHzXZKRtVknprMU3_Mi_DTv_faonduRSDbADfYwvo_UupDtPVONN30xBvDz22PdleqKHkp1LezE5XT809nX88X6i3_DToZuTU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733885425</pqid></control><display><type>article</type><title>MRI measurements of carotid plaque in the atherosclerosis risk in communities (ARIC) study: Methods, reliability and descriptive statistics</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Wasserman, Bruce A. ; Astor, Brad C. ; Sharrett, A. Richey ; Swingen, Cory ; Catellier, Diane</creator><creatorcontrib>Wasserman, Bruce A. ; Astor, Brad C. ; Sharrett, A. Richey ; Swingen, Cory ; Catellier, Diane</creatorcontrib><description>Purpose:
To measure carotid plaque components using MRI and estimate reliability in the population‐based Atherosclerosis Risk in Communities (ARIC) study.
Materials and Methods:
Contrast‐enhanced high‐resolution (0.51 × 0.58 × 2 mm3) MRI images were acquired through internal (ICA) and common carotid arteries (CCA) of 2066 ARIC participants at four sites. Sixty‐one exams were repeated and 164 pairs had repeated interpretations. Plaque component thicknesses, areas and volumes over eight slices (1.6‐cm segment) were measured. Intraplaque hemorrhage was recorded. Reliability was evaluated by intraclass correlations and κ statistics.
Results:
There were 1769 successful MRI exams (mean age 71 years; 57% females; 81% white; 19% African‐Americans). Repeat scan reliability was highest for CCA lumen area (0.94) and maximum wall thickness (0.89), ICA lumen area (0.89) and maximum wall thickness (0.77) and total wall volume (0.79), and lowest for small structures—core volume (0.30) and mean cap thickness (0.38). Overall reliability was primarily related to reader variability rather than scan acquisition. K's for presence of core, calcification and hemorrhage were fair to good. White men had the thickest plaques (average maximum ICA wall thickness = 2.3 mm) and the most cores (34%).
Conclusion:
The most important limiting factor for MRI measurements of plaque components is reader variability. Measurement error depends largely on the analyzed structure's size. J. Magn. Reson. Imaging 2010; 31: 406–415. © 2010 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.22043</identifier><identifier>PMID: 20099354</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>atherosclerosis ; Carotid Stenosis - diagnosis ; Carotid Stenosis - epidemiology ; Comorbidity ; Data Interpretation, Statistical ; epidemiology ; Female ; Humans ; Incidence ; Intracranial Arteriosclerosis - diagnosis ; Intracranial Arteriosclerosis - epidemiology ; Magnetic Resonance Angiography - statistics & numerical data ; magnetic resonance imaging ; Male ; Middle Aged ; plaque ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Sensitivity and Specificity ; statistics</subject><ispartof>Journal of magnetic resonance imaging, 2010-02, Vol.31 (2), p.406-415</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>2010 Wiley-Liss, Inc. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5233-88a338be8bfdcfe9684c202bdffe581cc6aade81bacc860545f7c2f39ec40bc13</citedby><cites>FETCH-LOGICAL-c5233-88a338be8bfdcfe9684c202bdffe581cc6aade81bacc860545f7c2f39ec40bc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.22043$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.22043$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20099354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wasserman, Bruce A.</creatorcontrib><creatorcontrib>Astor, Brad C.</creatorcontrib><creatorcontrib>Sharrett, A. Richey</creatorcontrib><creatorcontrib>Swingen, Cory</creatorcontrib><creatorcontrib>Catellier, Diane</creatorcontrib><title>MRI measurements of carotid plaque in the atherosclerosis risk in communities (ARIC) study: Methods, reliability and descriptive statistics</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose:
To measure carotid plaque components using MRI and estimate reliability in the population‐based Atherosclerosis Risk in Communities (ARIC) study.
Materials and Methods:
Contrast‐enhanced high‐resolution (0.51 × 0.58 × 2 mm3) MRI images were acquired through internal (ICA) and common carotid arteries (CCA) of 2066 ARIC participants at four sites. Sixty‐one exams were repeated and 164 pairs had repeated interpretations. Plaque component thicknesses, areas and volumes over eight slices (1.6‐cm segment) were measured. Intraplaque hemorrhage was recorded. Reliability was evaluated by intraclass correlations and κ statistics.
Results:
There were 1769 successful MRI exams (mean age 71 years; 57% females; 81% white; 19% African‐Americans). Repeat scan reliability was highest for CCA lumen area (0.94) and maximum wall thickness (0.89), ICA lumen area (0.89) and maximum wall thickness (0.77) and total wall volume (0.79), and lowest for small structures—core volume (0.30) and mean cap thickness (0.38). Overall reliability was primarily related to reader variability rather than scan acquisition. K's for presence of core, calcification and hemorrhage were fair to good. White men had the thickest plaques (average maximum ICA wall thickness = 2.3 mm) and the most cores (34%).
Conclusion:
The most important limiting factor for MRI measurements of plaque components is reader variability. Measurement error depends largely on the analyzed structure's size. J. Magn. Reson. Imaging 2010; 31: 406–415. © 2010 Wiley‐Liss, Inc.</description><subject>atherosclerosis</subject><subject>Carotid Stenosis - diagnosis</subject><subject>Carotid Stenosis - epidemiology</subject><subject>Comorbidity</subject><subject>Data Interpretation, Statistical</subject><subject>epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intracranial Arteriosclerosis - diagnosis</subject><subject>Intracranial Arteriosclerosis - epidemiology</subject><subject>Magnetic Resonance Angiography - statistics & numerical data</subject><subject>magnetic resonance imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>plaque</subject><subject>Reproducibility of Results</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>statistics</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdtu1DAQhiNERUvhhgdAvuOgpjh2nDhcIJVVKYu6RS2nS8uxJ-y0OSy207LPwEvjsO0KbrgZjzTf_DOeP0meZPQwo5S9uuwcHjJGc34v2csEYykTsrgfcyp4mkla7iYPvb-klFZVLh4ku2zKuMj3kl-LiznpQPvRQQd98GRoiNFuCGjJqtU_RiDYk7AEomNwgzftFNETh_5qqpmh68YeA4Inz48u5rMXxIfRrl-TBYTlYP0BcdCirrHFsCa6t8SCNw5XAa8hsjqgD2j8o2Sn0a2Hx7fvfvLl3fHn2fv09OPJfHZ0mhrBOE-l1JzLGmTdWNNAVcjcMMpq2zQgZGZMobUFmdXaGFlQkYumNKzhFZic1ibj-8mbje5qrDuwJn7b6VatHHbardWgUf1b6XGpvg_XilUFl0URBZ7dCrghHsgH1aE30La6h2H0qoz7SZEzEcmXG9LEm3kHzXZKRtVknprMU3_Mi_DTv_faonduRSDbADfYwvo_UupDtPVONN30xBvDz22PdleqKHkp1LezE5XT809nX88X6i3_DToZuTU</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Wasserman, Bruce A.</creator><creator>Astor, Brad C.</creator><creator>Sharrett, A. Richey</creator><creator>Swingen, Cory</creator><creator>Catellier, Diane</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201002</creationdate><title>MRI measurements of carotid plaque in the atherosclerosis risk in communities (ARIC) study: Methods, reliability and descriptive statistics</title><author>Wasserman, Bruce A. ; Astor, Brad C. ; Sharrett, A. Richey ; Swingen, Cory ; Catellier, Diane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5233-88a338be8bfdcfe9684c202bdffe581cc6aade81bacc860545f7c2f39ec40bc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>atherosclerosis</topic><topic>Carotid Stenosis - diagnosis</topic><topic>Carotid Stenosis - epidemiology</topic><topic>Comorbidity</topic><topic>Data Interpretation, Statistical</topic><topic>epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intracranial Arteriosclerosis - diagnosis</topic><topic>Intracranial Arteriosclerosis - epidemiology</topic><topic>Magnetic Resonance Angiography - statistics & numerical data</topic><topic>magnetic resonance imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>plaque</topic><topic>Reproducibility of Results</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>statistics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wasserman, Bruce A.</creatorcontrib><creatorcontrib>Astor, Brad C.</creatorcontrib><creatorcontrib>Sharrett, A. Richey</creatorcontrib><creatorcontrib>Swingen, Cory</creatorcontrib><creatorcontrib>Catellier, Diane</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wasserman, Bruce A.</au><au>Astor, Brad C.</au><au>Sharrett, A. Richey</au><au>Swingen, Cory</au><au>Catellier, Diane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI measurements of carotid plaque in the atherosclerosis risk in communities (ARIC) study: Methods, reliability and descriptive statistics</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2010-02</date><risdate>2010</risdate><volume>31</volume><issue>2</issue><spage>406</spage><epage>415</epage><pages>406-415</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose:
To measure carotid plaque components using MRI and estimate reliability in the population‐based Atherosclerosis Risk in Communities (ARIC) study.
Materials and Methods:
Contrast‐enhanced high‐resolution (0.51 × 0.58 × 2 mm3) MRI images were acquired through internal (ICA) and common carotid arteries (CCA) of 2066 ARIC participants at four sites. Sixty‐one exams were repeated and 164 pairs had repeated interpretations. Plaque component thicknesses, areas and volumes over eight slices (1.6‐cm segment) were measured. Intraplaque hemorrhage was recorded. Reliability was evaluated by intraclass correlations and κ statistics.
Results:
There were 1769 successful MRI exams (mean age 71 years; 57% females; 81% white; 19% African‐Americans). Repeat scan reliability was highest for CCA lumen area (0.94) and maximum wall thickness (0.89), ICA lumen area (0.89) and maximum wall thickness (0.77) and total wall volume (0.79), and lowest for small structures—core volume (0.30) and mean cap thickness (0.38). Overall reliability was primarily related to reader variability rather than scan acquisition. K's for presence of core, calcification and hemorrhage were fair to good. White men had the thickest plaques (average maximum ICA wall thickness = 2.3 mm) and the most cores (34%).
Conclusion:
The most important limiting factor for MRI measurements of plaque components is reader variability. Measurement error depends largely on the analyzed structure's size. J. Magn. Reson. Imaging 2010; 31: 406–415. © 2010 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20099354</pmid><doi>10.1002/jmri.22043</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | atherosclerosis Carotid Stenosis - diagnosis Carotid Stenosis - epidemiology Comorbidity Data Interpretation, Statistical epidemiology Female Humans Incidence Intracranial Arteriosclerosis - diagnosis Intracranial Arteriosclerosis - epidemiology Magnetic Resonance Angiography - statistics & numerical data magnetic resonance imaging Male Middle Aged plaque Reproducibility of Results Risk Assessment Risk Factors Sensitivity and Specificity statistics |
| title | MRI measurements of carotid plaque in the atherosclerosis risk in communities (ARIC) study: Methods, reliability and descriptive statistics |
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