Delivery dependence of early proximal bicarbonate reabsorption in the rat in respiratory acidosis and alkalosis
In the intact rat kidney, bicarbonate reabsorption in the early proximal tubule (EP) is strongly dependent on delivery. Independent of delivery, metabolic acidosis stimulates EP bicarbonate reabsorption. In this study, we investigated whether systemic pH changes induced by acute or chronic respirato...
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| Veröffentlicht in: | The Journal of clinical investigation 1991-02, Vol.87 (2), p.631-638 |
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| description | In the intact rat kidney, bicarbonate reabsorption in the early proximal tubule (EP) is strongly dependent on delivery. Independent of delivery, metabolic acidosis stimulates EP bicarbonate reabsorption. In this study, we investigated whether systemic pH changes induced by acute or chronic respiratory acid-base disorders also affect EP HCO3- reabsorption, independent of delivery (FLHCO3, filtered load of bicarbonate). Hypercapnia was induced in rats acutely (1-3 h) and chronically (4-5 d) by increasing inspired PCO2. Hypocapnia was induced acutely (1-3 h) by mechanical hyperventilation, and chronically (4-5 d) using hypoxemia to stimulate ventilation. When compared with normocapneic rats with similar FLHCO3, no stimulation of EP or overall proximal HCO3 reabsorption was found with either acute hypercapnia (PaCO2 = 74 mmHg, pH = 7.23) or chronic hypercapnia (PaCO2 = 84 mmHg, pH = 7.31). Acute hypocapnia (PaCO2 = 29 mmHg, pH = 7.56) did not suppress EP or overall HCO3 reabsorption. Chronic hypocapnia (PaCO2 = 26 mmHg, pH = 7.54) reduced proximal HCO3 reabsorption, but this effect was reversed when FLHCO3 was increased to levels comparable to euvolemic normocapneic rats. Thus, when delivery is accounted for, we could find no additional stimulation of proximal bicarbonate reabsorption in respiratory acidosis and, except at low delivery rates, no reduction in bicarbonate reabsorption in respiratory alkalosis. |
| doi_str_mv | 10.1172/JCI115040 |
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N ; MADDOX, D. A ; GENNARI, F. J</creator><creatorcontrib>SANTELLA, R. N ; MADDOX, D. A ; GENNARI, F. J</creatorcontrib><description>In the intact rat kidney, bicarbonate reabsorption in the early proximal tubule (EP) is strongly dependent on delivery. Independent of delivery, metabolic acidosis stimulates EP bicarbonate reabsorption. In this study, we investigated whether systemic pH changes induced by acute or chronic respiratory acid-base disorders also affect EP HCO3- reabsorption, independent of delivery (FLHCO3, filtered load of bicarbonate). Hypercapnia was induced in rats acutely (1-3 h) and chronically (4-5 d) by increasing inspired PCO2. Hypocapnia was induced acutely (1-3 h) by mechanical hyperventilation, and chronically (4-5 d) using hypoxemia to stimulate ventilation. When compared with normocapneic rats with similar FLHCO3, no stimulation of EP or overall proximal HCO3 reabsorption was found with either acute hypercapnia (PaCO2 = 74 mmHg, pH = 7.23) or chronic hypercapnia (PaCO2 = 84 mmHg, pH = 7.31). Acute hypocapnia (PaCO2 = 29 mmHg, pH = 7.56) did not suppress EP or overall HCO3 reabsorption. Chronic hypocapnia (PaCO2 = 26 mmHg, pH = 7.54) reduced proximal HCO3 reabsorption, but this effect was reversed when FLHCO3 was increased to levels comparable to euvolemic normocapneic rats. Thus, when delivery is accounted for, we could find no additional stimulation of proximal bicarbonate reabsorption in respiratory acidosis and, except at low delivery rates, no reduction in bicarbonate reabsorption in respiratory alkalosis.</description><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/JCI115040</identifier><identifier>PMID: 1991847</identifier><identifier>CODEN: JCINAO</identifier><language>eng</language><publisher>Ann Arbor, MI: American Society for Clinical Investigation</publisher><subject>Acidosis, Respiratory - etiology ; Acidosis, Respiratory - metabolism ; Alkalosis, Respiratory - etiology ; Alkalosis, Respiratory - metabolism ; Animals ; Bicarbonates - metabolism ; Biological and medical sciences ; Blood gas. Hemoglobin. Myoglobin. Hemotissulary gas exchange. Acid-base balance ; Fundamental and applied biological sciences. Psychology ; Hypercapnia - complications ; Hypercapnia - metabolism ; Kidney Tubules, Proximal - metabolism ; Male ; Rats ; Rats, Inbred Strains ; Vertebrates: respiratory system</subject><ispartof>The Journal of clinical investigation, 1991-02, Vol.87 (2), p.631-638</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-48329498b0621905e9fee3da83244f2496284c0ccd8034f59e6ea78248dfa9ee3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC296353/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC296353/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5407914$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1991847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SANTELLA, R. N</creatorcontrib><creatorcontrib>MADDOX, D. A</creatorcontrib><creatorcontrib>GENNARI, F. J</creatorcontrib><title>Delivery dependence of early proximal bicarbonate reabsorption in the rat in respiratory acidosis and alkalosis</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>In the intact rat kidney, bicarbonate reabsorption in the early proximal tubule (EP) is strongly dependent on delivery. Independent of delivery, metabolic acidosis stimulates EP bicarbonate reabsorption. In this study, we investigated whether systemic pH changes induced by acute or chronic respiratory acid-base disorders also affect EP HCO3- reabsorption, independent of delivery (FLHCO3, filtered load of bicarbonate). Hypercapnia was induced in rats acutely (1-3 h) and chronically (4-5 d) by increasing inspired PCO2. Hypocapnia was induced acutely (1-3 h) by mechanical hyperventilation, and chronically (4-5 d) using hypoxemia to stimulate ventilation. When compared with normocapneic rats with similar FLHCO3, no stimulation of EP or overall proximal HCO3 reabsorption was found with either acute hypercapnia (PaCO2 = 74 mmHg, pH = 7.23) or chronic hypercapnia (PaCO2 = 84 mmHg, pH = 7.31). Acute hypocapnia (PaCO2 = 29 mmHg, pH = 7.56) did not suppress EP or overall HCO3 reabsorption. Chronic hypocapnia (PaCO2 = 26 mmHg, pH = 7.54) reduced proximal HCO3 reabsorption, but this effect was reversed when FLHCO3 was increased to levels comparable to euvolemic normocapneic rats. Thus, when delivery is accounted for, we could find no additional stimulation of proximal bicarbonate reabsorption in respiratory acidosis and, except at low delivery rates, no reduction in bicarbonate reabsorption in respiratory alkalosis.</description><subject>Acidosis, Respiratory - etiology</subject><subject>Acidosis, Respiratory - metabolism</subject><subject>Alkalosis, Respiratory - etiology</subject><subject>Alkalosis, Respiratory - metabolism</subject><subject>Animals</subject><subject>Bicarbonates - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood gas. Hemoglobin. Myoglobin. Hemotissulary gas exchange. Acid-base balance</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypercapnia - complications</subject><subject>Hypercapnia - metabolism</subject><subject>Kidney Tubules, Proximal - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: respiratory system</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctuEzEUhq0KVNLSRR8AyQuE1MWAb5OxFyxQoBdUiQ2srTOeM63BsQd7UpG3x1GiQFc-Pv93bvoJueTsPeed-PB1dcd5yxQ7IQvetrrRQuoXZMGY4I3ppH5Fzkr5yRhXqlWn5JQbw7XqFiR9xuCfMG_pgBPGAaNDmkaKkMOWTjn98WsItPcOcp8izEgzQl9SnmafIvWRzo81B_MuzFgmX-NU-4HzQyq-UIgDhfALwu73mrwcIRS8OLzn5Mf1l--r2-b-283d6tN946TRc6O0FEYZ3bOl4Ia1aEZEOUBNKzUKZZZCK8ecGzSTamwNLhE6LZQeRjAVPScf932nTb_GwWGcMwQ75XpO3toE3j5Xon-0D-nJCrOUraz17w71Of3eYJnt2heHIUDEtClWMyUNZ6KCV3vQ5VRKxvE4gzO7M8cezansm_-X-kfu3aj624MOxUEYM0TnyxFrFesMV_IvoKWZQg</recordid><startdate>19910201</startdate><enddate>19910201</enddate><creator>SANTELLA, R. N</creator><creator>MADDOX, D. A</creator><creator>GENNARI, F. J</creator><general>American Society for Clinical Investigation</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19910201</creationdate><title>Delivery dependence of early proximal bicarbonate reabsorption in the rat in respiratory acidosis and alkalosis</title><author>SANTELLA, R. N ; MADDOX, D. A ; GENNARI, F. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-48329498b0621905e9fee3da83244f2496284c0ccd8034f59e6ea78248dfa9ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acidosis, Respiratory - etiology</topic><topic>Acidosis, Respiratory - metabolism</topic><topic>Alkalosis, Respiratory - etiology</topic><topic>Alkalosis, Respiratory - metabolism</topic><topic>Animals</topic><topic>Bicarbonates - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood gas. Hemoglobin. Myoglobin. Hemotissulary gas exchange. Acid-base balance</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypercapnia - complications</topic><topic>Hypercapnia - metabolism</topic><topic>Kidney Tubules, Proximal - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SANTELLA, R. N</creatorcontrib><creatorcontrib>MADDOX, D. A</creatorcontrib><creatorcontrib>GENNARI, F. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANTELLA, R. N</au><au>MADDOX, D. A</au><au>GENNARI, F. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delivery dependence of early proximal bicarbonate reabsorption in the rat in respiratory acidosis and alkalosis</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>1991-02-01</date><risdate>1991</risdate><volume>87</volume><issue>2</issue><spage>631</spage><epage>638</epage><pages>631-638</pages><issn>0021-9738</issn><eissn>1558-8238</eissn><coden>JCINAO</coden><abstract>In the intact rat kidney, bicarbonate reabsorption in the early proximal tubule (EP) is strongly dependent on delivery. Independent of delivery, metabolic acidosis stimulates EP bicarbonate reabsorption. In this study, we investigated whether systemic pH changes induced by acute or chronic respiratory acid-base disorders also affect EP HCO3- reabsorption, independent of delivery (FLHCO3, filtered load of bicarbonate). Hypercapnia was induced in rats acutely (1-3 h) and chronically (4-5 d) by increasing inspired PCO2. Hypocapnia was induced acutely (1-3 h) by mechanical hyperventilation, and chronically (4-5 d) using hypoxemia to stimulate ventilation. When compared with normocapneic rats with similar FLHCO3, no stimulation of EP or overall proximal HCO3 reabsorption was found with either acute hypercapnia (PaCO2 = 74 mmHg, pH = 7.23) or chronic hypercapnia (PaCO2 = 84 mmHg, pH = 7.31). Acute hypocapnia (PaCO2 = 29 mmHg, pH = 7.56) did not suppress EP or overall HCO3 reabsorption. Chronic hypocapnia (PaCO2 = 26 mmHg, pH = 7.54) reduced proximal HCO3 reabsorption, but this effect was reversed when FLHCO3 was increased to levels comparable to euvolemic normocapneic rats. Thus, when delivery is accounted for, we could find no additional stimulation of proximal bicarbonate reabsorption in respiratory acidosis and, except at low delivery rates, no reduction in bicarbonate reabsorption in respiratory alkalosis.</abstract><cop>Ann Arbor, MI</cop><pub>American Society for Clinical Investigation</pub><pmid>1991847</pmid><doi>10.1172/JCI115040</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acidosis, Respiratory - etiology Acidosis, Respiratory - metabolism Alkalosis, Respiratory - etiology Alkalosis, Respiratory - metabolism Animals Bicarbonates - metabolism Biological and medical sciences Blood gas. Hemoglobin. Myoglobin. Hemotissulary gas exchange. Acid-base balance Fundamental and applied biological sciences. Psychology Hypercapnia - complications Hypercapnia - metabolism Kidney Tubules, Proximal - metabolism Male Rats Rats, Inbred Strains Vertebrates: respiratory system |
| title | Delivery dependence of early proximal bicarbonate reabsorption in the rat in respiratory acidosis and alkalosis |
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