Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions

Oxidatively modified lipoproteins have been implicated in atherogenesis, but the mechanisms that promote oxidation in vivo have not been identified. Myeloperoxidase, a heme protein secreted by activated macrophages, generates reactive intermediates that oxidize lipoproteins in vitro. To explore the...

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Veröffentlicht in:	The Journal of clinical investigation 1994-07, Vol.94 (1), p.437-444
Hauptverfasser:	Daugherty, A, Dunn, J L, Rateri, D L, Heinecke, J W
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteriosclerosis - enzymology Arteriosclerosis - etiology Free Radicals Humans Hypochlorous Acid - metabolism Immunohistochemistry Lipoproteins - metabolism Macrophages - physiology Peroxidase - analysis Peroxidase - physiology
Online-Zugang:	Volltext
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