Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

The authors have established a method for the analysis of gene expression in tissue specimens preserved in formaldehyde. The expression profile of tissue adjacent to primary hepatocellular carcinoma, rather than the cancer itself, is associated with late recurrence. This finding, together with other...

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Veröffentlicht in:	The New England journal of medicine 2008-11, Vol.359 (19), p.1995-2004
Hauptverfasser:	Hoshida, Yujin, Villanueva, Augusto, Kobayashi, Masahiro, Peix, Judit, Chiang, Derek Y, Camargo, Amy, Gupta, Supriya, Moore, Jamie, Wrobel, Matthew J, Lerner, Jim, Reich, Michael, Chan, Jennifer A, Glickman, Jonathan N, Ikeda, Kenji, Hashimoto, Masaji, Watanabe, Goro, Daidone, Maria G, Roayaie, Sasan, Schwartz, Myron, Thung, Swan, Salvesen, Helga B, Gabriel, Stacey, Mazzaferro, Vincenzo, Bruix, Jordi, Friedman, Scott L, Kumada, Hiromitsu, Llovet, Josep M, Golub, Todd R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Feasibility Studies Female Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic General aspects Genome-Wide Association Study Hospitals Humans Liver - pathology Liver cancer Liver cirrhosis Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Methods Middle Aged Multivariate Analysis Neoplasm Recurrence, Local - genetics Oligonucleotide Array Sequence Analysis - methods Paraffin Embedding - methods Polymerase Chain Reaction Prognosis Surgery Survival Analysis Tissue Fixation - methods Tumors
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