Sustained morphine‐mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf‐1‐selective siRNA

BACKGROUND AND PURPOSE Long‐term morphine treatment enhances pain neurotransmitter [such as calcitonin gene‐related peptide (CGRP)] levels in the spinal cord. It has been suggested previously that increased spinal CGRP may contribute to sustained morphine‐mediated paradoxical pain sensitization and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 2010-09, Vol.161 (1), p.51-64
Hauptverfasser:	Tumati, S, Roeske, WR, Largent‐Milnes, T, Wang, R, Vanderah, TW, Varga, EV
Format:	Artikel
Sprache:	eng
Schlagworte:	allodynia analgesic tolerance Animals CGRP hyperalgesia Hyperalgesia - chemically induced Hyperalgesia - prevention & control Injections, Spinal Kinases Male MAP Kinase Kinase Kinases - antagonists & inhibitors MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism Morphine - pharmacology opioid Pain Proto-Oncogene Proteins c-raf Raf‐1 Rats Rats, Sprague-Dawley Research Papers RNA, Small Interfering - administration & dosage RNA, Small Interfering - pharmacology Rodents Spinal cord Spinal Cord - drug effects Spinal Cord - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!