A new role for bicarbonate in mucus formation

The impact of small anions on the physical properties of gel-forming mucin has been almost overlooked relative to that of cations. Recently, based on the coincident abnormalities in HCO(3)(-) secretion and abnormal mucus formed in the hereditary disease cystic fibrosis (CF), HCO(3)(-) was hypothesiz...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2010-10, Vol.299 (4), p.L542-L549
Hauptverfasser:	Chen, Eric Y T, Yang, Ning, Quinton, Paul M, Chin, Wei-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Bicarbonates - metabolism Body fluids Calcium Calcium - metabolism Cells Cystic fibrosis Exocytosis - physiology Humans Ions Lung Neoplasms - metabolism Lung Neoplasms - pathology Mucins - metabolism Mucus - metabolism Physiology Pulmonary Alveoli - metabolism Respiratory Mucosa - metabolism Secretory Vesicles - metabolism Tumor Cells, Cultured Viscosity
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