A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway
The Chinese herb modified Yi Guan Jian (mYGJ) is an effective regimen that is usually used in outpatients with chronic liver diseases such as fibrosis and cirrhosis. However, the mechanism for the action of mYGJ on liver fibrosis is not yet clear. In this study, we found that mYGJ induced hepatic st...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2011-01, Vol.2011 (2011), p.1-8 |
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| creator | Lin, Hung-Jen Tseng, Ching-Ping Lin, Chia-Fan Liao, Mei-Huei Chen, Chuan-Mu Kao, Shung-Te Cheng, Ju-Chien |
| description | The Chinese herb modified Yi Guan Jian (mYGJ) is an effective regimen that is usually used in outpatients with chronic liver diseases such as fibrosis and cirrhosis. However, the mechanism for the action of mYGJ on liver fibrosis is not yet clear. In this study, we found that mYGJ induced hepatic stellate cells (HSCs) apoptosis concomitant with the downregulation of Bcl-2 expression and slight elevation of Bax level. Moreover, the reactive oxygen species (ROS) were generated in the early stages of mYGJ-induced HSCs apoptosis to facilitate calcium and cytochrome c release from the mitochondria to cytosol. Subsequently, caspase 9 and caspase 3 were activated. Furthermore, the activation of ER stress-associated caspase 12 in HSCs was also evaluated. Together, we report the first evidence-based study to demonstrate that mYGJ decoction induces HSCs apoptosis through ROS accumulation and the intrinsic apoptosis pathway. These findings provide rationale for further clinical investigation of traditional Chinese medicine recipes against liver fibrosis. |
| doi_str_mv | 10.1155/2011/459531 |
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However, the mechanism for the action of mYGJ on liver fibrosis is not yet clear. In this study, we found that mYGJ induced hepatic stellate cells (HSCs) apoptosis concomitant with the downregulation of Bcl-2 expression and slight elevation of Bax level. Moreover, the reactive oxygen species (ROS) were generated in the early stages of mYGJ-induced HSCs apoptosis to facilitate calcium and cytochrome c release from the mitochondria to cytosol. Subsequently, caspase 9 and caspase 3 were activated. Furthermore, the activation of ER stress-associated caspase 12 in HSCs was also evaluated. Together, we report the first evidence-based study to demonstrate that mYGJ decoction induces HSCs apoptosis through ROS accumulation and the intrinsic apoptosis pathway. These findings provide rationale for further clinical investigation of traditional Chinese medicine recipes against liver fibrosis.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2011/459531</identifier><identifier>PMID: 20976079</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Angelica sinensis ; Apoptosis ; Astragalus membranaceus ; Bcl-2 protein ; Biochemistry ; Calcium ; Caspase ; Caspase-12 ; Caspase-3 ; Caspase-9 ; Cell growth ; Cirrhosis ; Cytochrome ; Cytochrome c ; Cytosol ; Eupolyphaga sinensis ; Fibrosis ; Free radicals ; Glehnia littoralis ; Hepatitis ; Herbal medicine ; Kinases ; Liver ; Liver cirrhosis ; Liver diseases ; Lycium barbarum ; Manufacturers ; Mitochondria ; Ophiopogon japonicus ; Pelodiscus sinensis ; Pharmaceutical industry ; Physiology ; Reactive oxygen species ; Rehmannia glutinosa ; RNA polymerase ; Rodents ; Stellate cells ; Toxicology ; Traditional Chinese medicine ; Trionyx ; Umbelliferae</subject><ispartof>Evidence-based complementary and alternative medicine, 2011-01, Vol.2011 (2011), p.1-8</ispartof><rights>Copyright © 2011 Hung-Jen Lin et al.</rights><rights>Copyright © 2011 Hung-Jen Lin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2011 Hung-Jen Lin et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-bb170d0c96ca07ff51b0a7dc968ed1b797009b178421e2555fa63f62d6d84fc83</citedby><cites>FETCH-LOGICAL-c493t-bb170d0c96ca07ff51b0a7dc968ed1b797009b178421e2555fa63f62d6d84fc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957151/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957151/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20976079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Hung-Jen</creatorcontrib><creatorcontrib>Tseng, Ching-Ping</creatorcontrib><creatorcontrib>Lin, Chia-Fan</creatorcontrib><creatorcontrib>Liao, Mei-Huei</creatorcontrib><creatorcontrib>Chen, Chuan-Mu</creatorcontrib><creatorcontrib>Kao, Shung-Te</creatorcontrib><creatorcontrib>Cheng, Ju-Chien</creatorcontrib><title>A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>The Chinese herb modified Yi Guan Jian (mYGJ) is an effective regimen that is usually used in outpatients with chronic liver diseases such as fibrosis and cirrhosis. However, the mechanism for the action of mYGJ on liver fibrosis is not yet clear. In this study, we found that mYGJ induced hepatic stellate cells (HSCs) apoptosis concomitant with the downregulation of Bcl-2 expression and slight elevation of Bax level. Moreover, the reactive oxygen species (ROS) were generated in the early stages of mYGJ-induced HSCs apoptosis to facilitate calcium and cytochrome c release from the mitochondria to cytosol. Subsequently, caspase 9 and caspase 3 were activated. Furthermore, the activation of ER stress-associated caspase 12 in HSCs was also evaluated. Together, we report the first evidence-based study to demonstrate that mYGJ decoction induces HSCs apoptosis through ROS accumulation and the intrinsic apoptosis pathway. These findings provide rationale for further clinical investigation of traditional Chinese medicine recipes against liver fibrosis.</description><subject>Angelica sinensis</subject><subject>Apoptosis</subject><subject>Astragalus membranaceus</subject><subject>Bcl-2 protein</subject><subject>Biochemistry</subject><subject>Calcium</subject><subject>Caspase</subject><subject>Caspase-12</subject><subject>Caspase-3</subject><subject>Caspase-9</subject><subject>Cell growth</subject><subject>Cirrhosis</subject><subject>Cytochrome</subject><subject>Cytochrome c</subject><subject>Cytosol</subject><subject>Eupolyphaga sinensis</subject><subject>Fibrosis</subject><subject>Free radicals</subject><subject>Glehnia littoralis</subject><subject>Hepatitis</subject><subject>Herbal medicine</subject><subject>Kinases</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Lycium barbarum</subject><subject>Manufacturers</subject><subject>Mitochondria</subject><subject>Ophiopogon japonicus</subject><subject>Pelodiscus sinensis</subject><subject>Pharmaceutical industry</subject><subject>Physiology</subject><subject>Reactive oxygen species</subject><subject>Rehmannia glutinosa</subject><subject>RNA polymerase</subject><subject>Rodents</subject><subject>Stellate cells</subject><subject>Toxicology</subject><subject>Traditional Chinese 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Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway</title><author>Lin, Hung-Jen ; Tseng, Ching-Ping ; Lin, Chia-Fan ; Liao, Mei-Huei ; Chen, Chuan-Mu ; Kao, Shung-Te ; Cheng, Ju-Chien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-bb170d0c96ca07ff51b0a7dc968ed1b797009b178421e2555fa63f62d6d84fc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Angelica sinensis</topic><topic>Apoptosis</topic><topic>Astragalus membranaceus</topic><topic>Bcl-2 protein</topic><topic>Biochemistry</topic><topic>Calcium</topic><topic>Caspase</topic><topic>Caspase-12</topic><topic>Caspase-3</topic><topic>Caspase-9</topic><topic>Cell growth</topic><topic>Cirrhosis</topic><topic>Cytochrome</topic><topic>Cytochrome c</topic><topic>Cytosol</topic><topic>Eupolyphaga sinensis</topic><topic>Fibrosis</topic><topic>Free radicals</topic><topic>Glehnia littoralis</topic><topic>Hepatitis</topic><topic>Herbal medicine</topic><topic>Kinases</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Lycium barbarum</topic><topic>Manufacturers</topic><topic>Mitochondria</topic><topic>Ophiopogon japonicus</topic><topic>Pelodiscus sinensis</topic><topic>Pharmaceutical industry</topic><topic>Physiology</topic><topic>Reactive oxygen species</topic><topic>Rehmannia glutinosa</topic><topic>RNA polymerase</topic><topic>Rodents</topic><topic>Stellate cells</topic><topic>Toxicology</topic><topic>Traditional Chinese medicine</topic><topic>Trionyx</topic><topic>Umbelliferae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Hung-Jen</creatorcontrib><creatorcontrib>Tseng, Ching-Ping</creatorcontrib><creatorcontrib>Lin, Chia-Fan</creatorcontrib><creatorcontrib>Liao, Mei-Huei</creatorcontrib><creatorcontrib>Chen, Chuan-Mu</creatorcontrib><creatorcontrib>Kao, 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Ju-Chien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>The Chinese herb modified Yi Guan Jian (mYGJ) is an effective regimen that is usually used in outpatients with chronic liver diseases such as fibrosis and cirrhosis. However, the mechanism for the action of mYGJ on liver fibrosis is not yet clear. In this study, we found that mYGJ induced hepatic stellate cells (HSCs) apoptosis concomitant with the downregulation of Bcl-2 expression and slight elevation of Bax level. Moreover, the reactive oxygen species (ROS) were generated in the early stages of mYGJ-induced HSCs apoptosis to facilitate calcium and cytochrome c release from the mitochondria to cytosol. Subsequently, caspase 9 and caspase 3 were activated. Furthermore, the activation of ER stress-associated caspase 12 in HSCs was also evaluated. Together, we report the first evidence-based study to demonstrate that mYGJ decoction induces HSCs apoptosis through ROS accumulation and the intrinsic apoptosis pathway. These findings provide rationale for further clinical investigation of traditional Chinese medicine recipes against liver fibrosis.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>20976079</pmid><doi>10.1155/2011/459531</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Angelica sinensis Apoptosis Astragalus membranaceus Bcl-2 protein Biochemistry Calcium Caspase Caspase-12 Caspase-3 Caspase-9 Cell growth Cirrhosis Cytochrome Cytochrome c Cytosol Eupolyphaga sinensis Fibrosis Free radicals Glehnia littoralis Hepatitis Herbal medicine Kinases Liver Liver cirrhosis Liver diseases Lycium barbarum Manufacturers Mitochondria Ophiopogon japonicus Pelodiscus sinensis Pharmaceutical industry Physiology Reactive oxygen species Rehmannia glutinosa RNA polymerase Rodents Stellate cells Toxicology Traditional Chinese medicine Trionyx Umbelliferae |
| title | A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway |
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