Effects of angiotensin II generated by an angiotensin converting enzyme-independent pathway on left ventricular performance in the conscious baboon

Human chymase is a serine proteinase that converts angiotensin (Ang) I to Ang II independent of angiotensin converting enzyme (ACE) in vitro. The effects of chymase on systemic hemodynamics and left ventricular function in vivo were studied in nine conscious baboons instrumented with a LV micromanom...

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Veröffentlicht in:	The Journal of clinical investigation 1995-04, Vol.95 (4), p.1519-1527
Hauptverfasser:	Hoit, B D, Shao, Y, Kinoshita, A, Gabel, M, Husain, A, Walsh, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin I - analogs & derivatives Angiotensin I - metabolism Angiotensin II - biosynthesis Angiotensin II - pharmacology Angiotensin Receptor Antagonists Animals Captopril - pharmacology Chymases Consciousness Diastole - drug effects Dose-Response Relationship, Drug Female Hemodynamics - drug effects Infusions, Intra-Arterial Male Mast Cells - metabolism Papio Peptidyl-Dipeptidase A - metabolism Serine Endopeptidases - metabolism Systole - drug effects Tissue Distribution Ventricular Function, Left - drug effects
Online-Zugang:	Volltext
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