Sept4/ARTS is required for stem cell apoptosis and tumor suppression

Inhibitor of Apoptosis Proteins (IAPs) are frequently overexpressed in tumors and have become promising targets for developing anti-cancer drugs. IAPs can be inhibited by natural antagonists, but a physiological requirement of mammalian IAP antagonists remains to be established. Here we show that de...

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Veröffentlicht in:	Genes & development 2010-10, Vol.24 (20), p.2282-2293
Hauptverfasser:	García-Fernández, María, Kissel, Holger, Brown, Samara, Gorenc, Travis, Schile, Andrew J, Rafii, Shahin, Larisch, Sarit, Steller, Hermann
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell Count Cells, Cultured Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Female Flow Cytometry GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Hematologic Neoplasms - genetics Hematologic Neoplasms - metabolism Hematologic Neoplasms - pathology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Immunoblotting Kaplan-Meier Estimate Lymphoid Tissue - metabolism Lymphoid Tissue - pathology Lymphoma - genetics Lymphoma - metabolism Lymphoma - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Research Paper Septins Stem Cells - cytology Stem Cells - metabolism Suppression, Genetic X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism
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