Muscle-derived collagen XIII regulates maturation of the skeletal neuromuscular junction

Formation, maturation, stabilization, and functional efficacy of the neuromuscular junction (NMJ) are orchestrated by transsynaptic and autocrine signals embedded within the synaptic cleft. Here, we demonstrate that collagen XIII, a nonfibrillar transmembrane collagen, is another such signal. We sho...

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Veröffentlicht in:	The Journal of neuroscience 2010-09, Vol.30 (37), p.12230-12241
Hauptverfasser:	Latvanlehto, Anne, Fox, Michael A, Sormunen, Raija, Tu, Hongmin, Oikarainen, Tuomo, Koski, Anu, Naumenko, Nikolay, Shakirzyanova, Anastasia, Kallio, Mika, Ilves, Mika, Giniatullin, Rashid, Sanes, Joshua R, Pihlajaniemi, Taina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autocrine Communication - genetics Autocrine Communication - physiology Cell Line Cells, Cultured Collagen Type XIII - deficiency Collagen Type XIII - genetics Collagen Type XIII - physiology Female Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Neurologic Mutants Muscle, Skeletal - growth & development Muscle, Skeletal - innervation Muscle, Skeletal - physiology Neuromuscular Junction - genetics Neuromuscular Junction - growth & development Neuromuscular Junction - secretion Synaptic Membranes - genetics Synaptic Membranes - physiology Synaptic Membranes - secretion Synaptic Transmission - genetics Synaptic Transmission - physiology
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