Carbachol- and elevated Ca(2+)-induced translocation of functionally active protein kinase C to the brush border of rabbit ileal Na+ absorbing cells

Protein kinase C is involved in mediating the effects of elevated Ca2+ in ileal villus Na+ absorbing cells to inhibit NaCl absorption. The present studies were undertaken to understand the mechanism by which this occurs. The effects of carbachol and the calcium ionophore A23187, agents which elevate...

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Veröffentlicht in:	The Journal of clinical investigation 1991-09, Vol.88 (3), p.855-863
Hauptverfasser:	Cohen, M E, Wesolek, J, McCullen, J, Rys-Sikora, K, Pandol, S, Rood, R P, Sharp, G W, Donowitz, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Animals Biological Transport Calcimycin - pharmacology Calcium - physiology Carbachol - pharmacology Diglycerides - analysis Ileum - metabolism In Vitro Techniques Male Microvilli - metabolism Protein Kinase C - analysis Protein Kinase C - metabolism Rabbits Sodium - metabolism
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