Relaxin Signaling in Uterine Fibroids

Uterine fibroid is the most common tumor of female reproductive organs. The role of relaxin signaling in leiomyoma development was analyzed. We used 23 matched pairs of leiomyoma and normal myometrium samples to compare the expression of relaxin family peptide receptors RXFP1 and RXFP2, caveolin 1,...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2009-04, Vol.1160 (1), p.374-378
Hauptverfasser:	Li, Zhen, Burzawa, Jennifer K., Troung, Anne, Feng, Shu, Agoulnik, Irina U., Tong, Xiaowen, Anderson, Matthew L., Kovanci, Ertug, Rajkovic, Aleksandar, Agoulnik, Alexander I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Blotting, Western Caveolin 1 - genetics Caveolin 1 - metabolism Cell Line, Tumor Desmin - genetics Desmin - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Humans Immunohistochemistry INSL3 leiomyoma Leiomyoma - metabolism Middle Aged Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Receptor Co-Repressor 1 Nuclear Receptor Co-Repressor 2 phospho-SMAD2 Phosphorylation - drug effects Rats Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Peptide - genetics Receptors, Peptide - metabolism relaxin Relaxin - metabolism Relaxin - pharmacology Relaxin - physiology Repressor Proteins - genetics Repressor Proteins - metabolism Signal Transduction Smad2 Protein - metabolism transforming growth factor Transforming Growth Factor beta - pharmacology
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