Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease
Background Experimental studies have linked hypomagnesemia with the development of vascular dysfunction, hypertension, and atherosclerosis. Prior clinical studies have yielded conflicting results but were limited by the use of self-reported magnesium intake or short follow-up periods. Methods We exa...
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| Veröffentlicht in: | The American heart journal 2010-10, Vol.160 (4), p.715-720 |
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| creator | Khan, Abigail May, MD Sullivan, Lisa, PhD McCabe, Elizabeth, MS, ScM Levy, Daniel, MD Vasan, Ramachandran S., MD Wang, Thomas J., MD |
| description | Background Experimental studies have linked hypomagnesemia with the development of vascular dysfunction, hypertension, and atherosclerosis. Prior clinical studies have yielded conflicting results but were limited by the use of self-reported magnesium intake or short follow-up periods. Methods We examined the relationship between serum magnesium concentration and incident hypertension, cardiovascular disease (CVD), and mortality in 3,531 middle-aged adult participants in the Framingham Heart Study offspring cohort. Analyses were performed using Cox proportional hazards regressions, adjusted for traditional CVD risk factors. Results Follow-up was 8 years for new-onset hypertension (551 events) and 20 years for CVD (554 events). There was no association between baseline serum magnesium and the development of hypertension (multivariable-adjusted hazards ratio per 0.15 mg/dL 1.03, 95% CI 0.92-1.15, P = .61), CVD (0.83, 95% CI 0.49-1.40, P = .49), or all-cause mortality (0.77, 95% CI 0.41-1.45, P = .42). Similar findings were observed in categorical analyses, in which serum magnesium was modeled in categories (2.2 mg/dL) or in quartiles. Conclusions In conclusion, data from this large, community-based cohort do not support the hypothesis that low serum magnesium is a risk factor for developing hypertension or CVD. |
| doi_str_mv | 10.1016/j.ahj.2010.06.036 |
| format | Article |
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Prior clinical studies have yielded conflicting results but were limited by the use of self-reported magnesium intake or short follow-up periods. Methods We examined the relationship between serum magnesium concentration and incident hypertension, cardiovascular disease (CVD), and mortality in 3,531 middle-aged adult participants in the Framingham Heart Study offspring cohort. Analyses were performed using Cox proportional hazards regressions, adjusted for traditional CVD risk factors. Results Follow-up was 8 years for new-onset hypertension (551 events) and 20 years for CVD (554 events). There was no association between baseline serum magnesium and the development of hypertension (multivariable-adjusted hazards ratio per 0.15 mg/dL 1.03, 95% CI 0.92-1.15, P = .61), CVD (0.83, 95% CI 0.49-1.40, P = .49), or all-cause mortality (0.77, 95% CI 0.41-1.45, P = .42). Similar findings were observed in categorical analyses, in which serum magnesium was modeled in categories (<1.5, 1.5-2.2, >2.2 mg/dL) or in quartiles. Conclusions In conclusion, data from this large, community-based cohort do not support the hypothesis that low serum magnesium is a risk factor for developing hypertension or CVD.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2010.06.036</identifier><identifier>PMID: 20934566</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - physiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cause of Death - trends ; Cholesterol ; Colorimetry ; Female ; Follow-Up Studies ; Health risk assessment ; Heart Diseases - blood ; Heart Diseases - epidemiology ; Humans ; Hypertension - blood ; Hypertension - epidemiology ; Incidence ; Magnesium ; Magnesium - blood ; Male ; Medical sciences ; Prognosis ; Retrospective Studies ; Risk Factors ; Studies ; Survival Rate - trends ; Time Factors ; United States - epidemiology</subject><ispartof>The American heart journal, 2010-10, Vol.160 (4), p.715-720</ispartof><rights>Mosby, Inc.</rights><rights>2010 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 2010</rights><rights>2010 Mosby, Inc. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c629t-b2d9dcaaf906cd3de82602313adaa165f5634138fbfd2b14edd73801fa0c03be3</citedby><cites>FETCH-LOGICAL-c629t-b2d9dcaaf906cd3de82602313adaa165f5634138fbfd2b14edd73801fa0c03be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1504640512?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23393465$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20934566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Abigail May, MD</creatorcontrib><creatorcontrib>Sullivan, Lisa, PhD</creatorcontrib><creatorcontrib>McCabe, Elizabeth, MS, ScM</creatorcontrib><creatorcontrib>Levy, Daniel, MD</creatorcontrib><creatorcontrib>Vasan, Ramachandran S., MD</creatorcontrib><creatorcontrib>Wang, Thomas J., MD</creatorcontrib><title>Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Background Experimental studies have linked hypomagnesemia with the development of vascular dysfunction, hypertension, and atherosclerosis. Prior clinical studies have yielded conflicting results but were limited by the use of self-reported magnesium intake or short follow-up periods. Methods We examined the relationship between serum magnesium concentration and incident hypertension, cardiovascular disease (CVD), and mortality in 3,531 middle-aged adult participants in the Framingham Heart Study offspring cohort. Analyses were performed using Cox proportional hazards regressions, adjusted for traditional CVD risk factors. Results Follow-up was 8 years for new-onset hypertension (551 events) and 20 years for CVD (554 events). There was no association between baseline serum magnesium and the development of hypertension (multivariable-adjusted hazards ratio per 0.15 mg/dL 1.03, 95% CI 0.92-1.15, P = .61), CVD (0.83, 95% CI 0.49-1.40, P = .49), or all-cause mortality (0.77, 95% CI 0.41-1.45, P = .42). Similar findings were observed in categorical analyses, in which serum magnesium was modeled in categories (<1.5, 1.5-2.2, >2.2 mg/dL) or in quartiles. Conclusions In conclusion, data from this large, community-based cohort do not support the hypothesis that low serum magnesium is a risk factor for developing hypertension or CVD.</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cause of Death - trends</subject><subject>Cholesterol</subject><subject>Colorimetry</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health risk assessment</subject><subject>Heart Diseases - blood</subject><subject>Heart Diseases - epidemiology</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - epidemiology</subject><subject>Incidence</subject><subject>Magnesium</subject><subject>Magnesium - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Survival Rate - trends</subject><subject>Time Factors</subject><subject>United States - epidemiology</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kk2P0zAQhiMEYsvCD-CCIiHEqWVsx04jpJVWK76kShyAszWxJ1u3qV3spKj_Hkctu7AHTvZonnc843eK4iWDBQOm3m0WuN4sOOQY1AKEelTMGDT1XNVV9biYAQCfL2sQF8WzlDY5VHypnhYXHBpRSaVmhV2h2ZahKzGlYBwOLviypeEXkS8TxXFX7vDWU3L5ht6Ww5rK6NI2TaL1cU9xIJ8m1ZQ1GK0LB0xm7DGW1iXCRM-LJx32iV6cz8vix8cP328-z1dfP325uV7NjeLNMG-5baxB7BpQxgpLS66ACybQIjIlO6lExcSyazvLW1aRtbVYAusQDIiWxGVxdaq7H9sdWUN-iNjrfXQ7jEcd0Ol_M96t9W04aN7IXAhygbfnAjH8HCkNeueSob5HT2FMupZ1lVuSLJOvH5CbMEafp9NMQqUqkIxnip0oE0NKkbq7XhjoyUK90dlCPVmoQelsYda8-nuIO8UfzzLw5gzkb8a-i-iNS_ecEBlUMnPvTxzlLz84ijoZR96QdZHMoG1w_23j6oHa9M67_OCWjpTup9WJa9Dfpl2bVo3lixS1FL8BUMjQJQ</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Khan, Abigail May, MD</creator><creator>Sullivan, Lisa, PhD</creator><creator>McCabe, Elizabeth, MS, ScM</creator><creator>Levy, Daniel, MD</creator><creator>Vasan, Ramachandran S., MD</creator><creator>Wang, Thomas J., MD</creator><general>Mosby, Inc</general><general>Mosby</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101001</creationdate><title>Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease</title><author>Khan, Abigail May, MD ; Sullivan, Lisa, PhD ; McCabe, Elizabeth, MS, ScM ; Levy, Daniel, MD ; Vasan, Ramachandran S., MD ; Wang, Thomas J., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c629t-b2d9dcaaf906cd3de82602313adaa165f5634138fbfd2b14edd73801fa0c03be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cause of Death - trends</topic><topic>Cholesterol</topic><topic>Colorimetry</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health risk assessment</topic><topic>Heart Diseases - blood</topic><topic>Heart Diseases - epidemiology</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - epidemiology</topic><topic>Incidence</topic><topic>Magnesium</topic><topic>Magnesium - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Survival Rate - trends</topic><topic>Time Factors</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Abigail May, MD</creatorcontrib><creatorcontrib>Sullivan, Lisa, PhD</creatorcontrib><creatorcontrib>McCabe, Elizabeth, MS, ScM</creatorcontrib><creatorcontrib>Levy, Daniel, MD</creatorcontrib><creatorcontrib>Vasan, Ramachandran S., MD</creatorcontrib><creatorcontrib>Wang, Thomas J., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Abigail May, MD</au><au>Sullivan, Lisa, PhD</au><au>McCabe, Elizabeth, MS, ScM</au><au>Levy, Daniel, MD</au><au>Vasan, Ramachandran S., MD</au><au>Wang, Thomas J., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>160</volume><issue>4</issue><spage>715</spage><epage>720</epage><pages>715-720</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Background Experimental studies have linked hypomagnesemia with the development of vascular dysfunction, hypertension, and atherosclerosis. Prior clinical studies have yielded conflicting results but were limited by the use of self-reported magnesium intake or short follow-up periods. Methods We examined the relationship between serum magnesium concentration and incident hypertension, cardiovascular disease (CVD), and mortality in 3,531 middle-aged adult participants in the Framingham Heart Study offspring cohort. Analyses were performed using Cox proportional hazards regressions, adjusted for traditional CVD risk factors. Results Follow-up was 8 years for new-onset hypertension (551 events) and 20 years for CVD (554 events). There was no association between baseline serum magnesium and the development of hypertension (multivariable-adjusted hazards ratio per 0.15 mg/dL 1.03, 95% CI 0.92-1.15, P = .61), CVD (0.83, 95% CI 0.49-1.40, P = .49), or all-cause mortality (0.77, 95% CI 0.41-1.45, P = .42). Similar findings were observed in categorical analyses, in which serum magnesium was modeled in categories (<1.5, 1.5-2.2, >2.2 mg/dL) or in quartiles. Conclusions In conclusion, data from this large, community-based cohort do not support the hypothesis that low serum magnesium is a risk factor for developing hypertension or CVD.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>20934566</pmid><doi>10.1016/j.ahj.2010.06.036</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cause of Death - trends Cholesterol Colorimetry Female Follow-Up Studies Health risk assessment Heart Diseases - blood Heart Diseases - epidemiology Humans Hypertension - blood Hypertension - epidemiology Incidence Magnesium Magnesium - blood Male Medical sciences Prognosis Retrospective Studies Risk Factors Studies Survival Rate - trends Time Factors United States - epidemiology |
| title | Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease |
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