Large non-coding RNAs: missing links in cancer?
Cellular homeostasis is achieved by the proper balance of regulatory networks that if disrupted can lead to cellular transformation. These cell circuits are fine-tuned and maintained by the coordinated function of proteins and non-coding RNAs (ncRNAs). In addition to the well-characterized protein c...
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| Veröffentlicht in: | Human molecular genetics 2010-10, Vol.19 (R2), p.R152-R161 |
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| container_title | Human molecular genetics |
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| creator | Huarte, Maite Rinn, John L. |
| description | Cellular homeostasis is achieved by the proper balance of regulatory networks that if disrupted can lead to cellular transformation. These cell circuits are fine-tuned and maintained by the coordinated function of proteins and non-coding RNAs (ncRNAs). In addition to the well-characterized protein coding and microRNAs constituents, large ncRNAs are also emerging as important regulatory molecules in tumor-suppressor and oncogenic pathways. Recent studies have revealed mechanistic insight of large ncRNAs regulating key cancer pathways at a transcriptional, post-transcriptional and epigenetic level. Here we synthesize these latest advances within the context of their mechanistic roles in regulating and maintaining cellular equilibrium. We posit that similar to protein-coding genes, large ncRNAs are a newly emerging class of oncogenic and tumor-suppressor genes. Our growing knowledge of the role of large ncRNAs in cellular transformation is pointing towards their potential use as biomarkers and targets for novel therapeutic approaches in the future. |
| doi_str_mv | 10.1093/hmg/ddq353 |
| format | Article |
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These cell circuits are fine-tuned and maintained by the coordinated function of proteins and non-coding RNAs (ncRNAs). In addition to the well-characterized protein coding and microRNAs constituents, large ncRNAs are also emerging as important regulatory molecules in tumor-suppressor and oncogenic pathways. Recent studies have revealed mechanistic insight of large ncRNAs regulating key cancer pathways at a transcriptional, post-transcriptional and epigenetic level. Here we synthesize these latest advances within the context of their mechanistic roles in regulating and maintaining cellular equilibrium. We posit that similar to protein-coding genes, large ncRNAs are a newly emerging class of oncogenic and tumor-suppressor genes. Our growing knowledge of the role of large ncRNAs in cellular transformation is pointing towards their potential use as biomarkers and targets for novel therapeutic approaches in the future.</description><identifier>ISSN: 0964-6906</identifier><identifier>EISSN: 1460-2083</identifier><identifier>DOI: 10.1093/hmg/ddq353</identifier><identifier>PMID: 20729297</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Humans ; Molecular and cellular biology ; Neoplasms - genetics ; RNA, Untranslated - genetics</subject><ispartof>Human molecular genetics, 2010-10, Vol.19 (R2), p.R152-R161</ispartof><rights>2015 INIST-CNRS</rights><rights>The Author 2010. Published by Oxford University Press. 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Our growing knowledge of the role of large ncRNAs in cellular transformation is pointing towards their potential use as biomarkers and targets for novel therapeutic approaches in the future.</description><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>Neoplasms - genetics</subject><subject>RNA, Untranslated - genetics</subject><issn>0964-6906</issn><issn>1460-2083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF2LEzEUhoMotlu92R8gcyOCMDbfmXixS-laK1YFUSx7E9JMMo2dZtqkFf33pkytehVezsN7ch4ArhF8haAk4_W2Gdf1njDyAAwR5bDEsCIPwRBKTksuIR-Aq5S-Q4g4JeIxGGAosMRSDMF4oWNji9CF0nS1D03x-eMkvS62PqVTan3YpMKHwuhgbLx9Ah453Sb79PyOwNfZmy_Tebn49PbddLIoDaXsUFLoNBPIWSS109pIKVeVc1wwrhFkhHLMKiMZXTmmIaJVnbPEMCciDKrICNz0vbvjamtrY8Mh6lbtot_q-Et12qv_J8GvVdP9UFgyIijMBS_OBbHbH206qHySsW2rg-2OSQlWIcIkppl82ZMmdilF6y5bEFQnwSoLVr3gDD_7918X9I_RDDw_AzoZ3bqYvfn0lyNUUCx45sqe8-lgf17mOm4UF0QwNV_eq9m3D2h2936pluQ3pW6Sdw</recordid><startdate>20101015</startdate><enddate>20101015</enddate><creator>Huarte, Maite</creator><creator>Rinn, John L.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101015</creationdate><title>Large non-coding RNAs: missing links in cancer?</title><author>Huarte, Maite ; Rinn, John L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-40fa571fe19afaac999b8ff6756a105346258c954bf5a0148d258920f5a37c183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>Neoplasms - genetics</topic><topic>RNA, Untranslated - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huarte, Maite</creatorcontrib><creatorcontrib>Rinn, John L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human molecular genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huarte, Maite</au><au>Rinn, John L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large non-coding RNAs: missing links in cancer?</atitle><jtitle>Human molecular genetics</jtitle><addtitle>Hum Mol Genet</addtitle><date>2010-10-15</date><risdate>2010</risdate><volume>19</volume><issue>R2</issue><spage>R152</spage><epage>R161</epage><pages>R152-R161</pages><issn>0964-6906</issn><eissn>1460-2083</eissn><abstract>Cellular homeostasis is achieved by the proper balance of regulatory networks that if disrupted can lead to cellular transformation. 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| issn | 0964-6906 1460-2083 |
| language | eng |
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| source | MEDLINE; Oxford Journals - Connect here FIRST to enable access; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Biological and medical sciences Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Humans Molecular and cellular biology Neoplasms - genetics RNA, Untranslated - genetics |
| title | Large non-coding RNAs: missing links in cancer? |
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