Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype

Alzheimer's disease (AD) is a neurodegenerative condition characterized histopathologically by neuritic plaques and neurofibrillary tangles. The objective of this transcriptional profiling study was to identify both neurosusceptibility and intrinsic neuroprotective factors at the molecular leve...

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Veröffentlicht in:	Molecular psychiatry 2011-08, Vol.16 (8), p.836-847
Hauptverfasser:	Conejero-Goldberg, C, Hyde, T M, Chen, S, Dreses-Werringloer, U, Herman, M M, Kleinman, J E, Davies, P, Goldberg, T E
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/191/2018 692/698/1688/1366/64 692/699/375/365/1283 Adult Adult and adolescent clinical studies Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E Apolipoprotein E3 - genetics Apolipoprotein E4 Apolipoprotein E4 - genetics Apolipoprotein E4 - metabolism Apolipoproteins Apolipoproteins E - biosynthesis Apolipoproteins E - genetics Autopsy Behavioral Sciences Bioinformatics Biological and medical sciences Biological Psychology Brain Brain research Calcium (mitochondrial) Cerebral Cortex - metabolism Cortex (somatosensory) Cortex (temporal) Databases, Genetic Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Development and progression Female Gene expression Gene Expression - genetics Genetic aspects Genetic Predisposition to Disease - genetics Genotype Genotype & phenotype Genotypes Health risk assessment Heterozygote Humans Male Medical research Medical sciences Medicine Medicine & Public Health Middle Aged Mitochondria Neurodegenerative diseases Neurofibrillary tangles Neurology Neuropathology Neuroprotection Neurosciences Organic mental disorders. Neuropsychology original-article Pathology Pharmacotherapy Physiological aspects Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk factors Senile plaques Signal Transduction - genetics Temporal gyrus Transcription
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