Protein 4.1 deficiency associated with an altered binding to the spectrin-actin complex of the red cell membrane skeleton

Protein 4.1 has been defined as a major component of the subcortical skeleton of erythrocytes. It binds the spectrin--actin scaffold through a 10-kD internal domain. This binding requires an essential 21-amino acid sequence motif, Motif I, which is retained by alternative splicing at the late stage...

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