Peripheral but crucial: A hydrophobic pocket (Tyr 706, Leu 337, and Met 336) for potent and selective inhibition of neuronal nitric oxide synthase

Selective inhibition of the neuronal isoform of nitric oxide synthase (nNOS) over endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) has become a promising strategy for the discovery of new therapeutic agents for neurodegenerative diseases. However, because of the hi...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-11, Vol.20 (21), p.6258-6261
Hauptverfasser:	Xue, Fengtian, Li, Huiying, Fang, Jianguo, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Crystal structure Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Medical sciences Miscellaneous Nitric oxide synthase Oxidoreductases Peripheral hydrophobic pocket Pharmacology. Drug treatments Pi-stacking Selective inhibitor
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