Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1

Interleukin 15 (IL-15) promotes the survival of natural killer (NK) cells by preventing apoptosis through mechanisms unknown at present. Here we identify Bim, Noxa and Mcl-1 as key regulators of IL-15-dependent survival of NK cells. IL-15 suppressed apoptosis by limiting Bim expression through the k...

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Veröffentlicht in:	Nature Immunology 2007-08, Vol.8 (8), p.856-863
Hauptverfasser:	Huntington, Nicholas D, Puthalakath, Hamsa, Gunn, Priscilla, Naik, Edwina, Michalak, Ewa M, Smyth, Mark J, Tabarias, Hyacinth, Degli-Esposti, Mariapia A, Dewson, Grant, Willis, Simon N, Motoyama, Noboru, Huang, David C S, Nutt, Stephen L, Tarlinton, David M, Strasser, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - immunology Apoptosis Regulatory Proteins - immunology Apoptosis Regulatory Proteins - metabolism Bcl-2-Like Protein 11 Biomedical and Life Sciences Biomedicine Cell Survival - immunology Flow Cytometry Forkhead Box Protein O3 Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism Immunoblotting Immunology Inactivation Infectious Diseases Interleukin-15 - immunology Interleukin-15 - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Membrane Proteins - immunology Membrane Proteins - metabolism Mice Mitogen-Activated Protein Kinase 3 - immunology Mitogen-Activated Protein Kinase 3 - metabolism Myeloid Cell Leukemia Sequence 1 Protein Neoplasm Proteins - immunology Neoplasm Proteins - metabolism Phosphatidylinositol 3-Kinases - immunology Phosphatidylinositol 3-Kinases - metabolism Polymerase Chain Reaction Proto-Oncogene Proteins - immunology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - immunology Proto-Oncogene Proteins c-bcl-2 - metabolism Survival
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